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Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China

PURPOSE: The relationship between childhood blood eosinophils and subtypes of allergic diseases remains understudied. This study aimed to examine the associations between childhood blood eosinophils and subtypes of asthma, rhinitis and dermatitis, as well as the modifying effect of age. METHODS: We...

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Autores principales: Hou, Xiangqing, Luo, Wenting, Gan, Hui, Chen, Tianhao, Sun, Baoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586638/
https://www.ncbi.nlm.nih.gov/pubmed/36259652
http://dx.doi.org/10.1080/07853890.2022.2134584
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author Hou, Xiangqing
Luo, Wenting
Gan, Hui
Chen, Tianhao
Sun, Baoqing
author_facet Hou, Xiangqing
Luo, Wenting
Gan, Hui
Chen, Tianhao
Sun, Baoqing
author_sort Hou, Xiangqing
collection PubMed
description PURPOSE: The relationship between childhood blood eosinophils and subtypes of allergic diseases remains understudied. This study aimed to examine the associations between childhood blood eosinophils and subtypes of asthma, rhinitis and dermatitis, as well as the modifying effect of age. METHODS: We obtained concurrent blood cell counts and serum Immunoglobulin E (IgE) test results in 5026 children (0–13, years) from First Affiliated Hospital of Guangzhou Medical University from 2014 to 2019. Generalized additive models with multivariable adjustments were utilized to model the exposure-response relationship between eosinophils and allergic symptoms. The robustness of the association was assessed in two age categories (<6, 6–13 years). RESULTS: The association of eosinophils with allergic asthma/rhinitis was positively nonlinear, with a plateau at levels of Q(4) (≥0.51, 10(9)/L). Conversely, exposure-response curves between eosinophils and the risk of non-allergic asthma and rhinitis were negatively linear, and especially, became statistically significant when levels of eosinophils were larger than Q(3) (≥0.30, 10(9)/L). Compared with their counterparts, school-aged children (6–13, years) with a higher level of blood eosinophils (≥0.35, 10(9)/L) were more likely to suffer from allergic asthma [relative excess risk due to interaction (RERI), 2.51; 95% CI, 1.24–3.78], allergic rhinitis (RERI, 2.79; 95% CI, 1.14–4.45) but not allergic dermatitis (RERI not significant). CONCLUSION: Higher eosinophil counts were associated with the increased risk of allergic subtype symptoms and the decreased risk of non-allergic subtypes in children. Moreover, the associations between eosinophils and allergic asthma/rhinitis were accentuated in the school-aged child. These findings may contribute to providing novel insights for clinical administration relevance of allergic-related symptoms. KEY MESSAGES: 1. There was a positively nonlinear association between childhood eosinophils and allergic asthma/rhinitis. 2. Age modified the associations between eosinophils and allergy-related outcomes. The associations of eosinophil with allergic asthma/rhinitis accentuated in the school-aged child (6–13, years).
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spelling pubmed-95866382022-10-22 Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China Hou, Xiangqing Luo, Wenting Gan, Hui Chen, Tianhao Sun, Baoqing Ann Med Pediatrics PURPOSE: The relationship between childhood blood eosinophils and subtypes of allergic diseases remains understudied. This study aimed to examine the associations between childhood blood eosinophils and subtypes of asthma, rhinitis and dermatitis, as well as the modifying effect of age. METHODS: We obtained concurrent blood cell counts and serum Immunoglobulin E (IgE) test results in 5026 children (0–13, years) from First Affiliated Hospital of Guangzhou Medical University from 2014 to 2019. Generalized additive models with multivariable adjustments were utilized to model the exposure-response relationship between eosinophils and allergic symptoms. The robustness of the association was assessed in two age categories (<6, 6–13 years). RESULTS: The association of eosinophils with allergic asthma/rhinitis was positively nonlinear, with a plateau at levels of Q(4) (≥0.51, 10(9)/L). Conversely, exposure-response curves between eosinophils and the risk of non-allergic asthma and rhinitis were negatively linear, and especially, became statistically significant when levels of eosinophils were larger than Q(3) (≥0.30, 10(9)/L). Compared with their counterparts, school-aged children (6–13, years) with a higher level of blood eosinophils (≥0.35, 10(9)/L) were more likely to suffer from allergic asthma [relative excess risk due to interaction (RERI), 2.51; 95% CI, 1.24–3.78], allergic rhinitis (RERI, 2.79; 95% CI, 1.14–4.45) but not allergic dermatitis (RERI not significant). CONCLUSION: Higher eosinophil counts were associated with the increased risk of allergic subtype symptoms and the decreased risk of non-allergic subtypes in children. Moreover, the associations between eosinophils and allergic asthma/rhinitis were accentuated in the school-aged child. These findings may contribute to providing novel insights for clinical administration relevance of allergic-related symptoms. KEY MESSAGES: 1. There was a positively nonlinear association between childhood eosinophils and allergic asthma/rhinitis. 2. Age modified the associations between eosinophils and allergy-related outcomes. The associations of eosinophil with allergic asthma/rhinitis accentuated in the school-aged child (6–13, years). Taylor & Francis 2022-10-19 /pmc/articles/PMC9586638/ /pubmed/36259652 http://dx.doi.org/10.1080/07853890.2022.2134584 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pediatrics
Hou, Xiangqing
Luo, Wenting
Gan, Hui
Chen, Tianhao
Sun, Baoqing
Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China
title Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China
title_full Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China
title_fullStr Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China
title_full_unstemmed Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China
title_short Childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in Southern China
title_sort childhood blood eosinophils and symptoms of allergic disorders: a cross-sectional study in southern china
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586638/
https://www.ncbi.nlm.nih.gov/pubmed/36259652
http://dx.doi.org/10.1080/07853890.2022.2134584
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