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Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine

Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer...

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Autores principales: Lai, Gui-hua, Wang, Fei, Nie, Duo-rui, Lei, Shu-jun, Wu, Zhuo-jun, Cao, Jian-xiong, Tang, Lan-lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586738/
https://www.ncbi.nlm.nih.gov/pubmed/36276846
http://dx.doi.org/10.1155/2022/2192654
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author Lai, Gui-hua
Wang, Fei
Nie, Duo-rui
Lei, Shu-jun
Wu, Zhuo-jun
Cao, Jian-xiong
Tang, Lan-lan
author_facet Lai, Gui-hua
Wang, Fei
Nie, Duo-rui
Lei, Shu-jun
Wu, Zhuo-jun
Cao, Jian-xiong
Tang, Lan-lan
author_sort Lai, Gui-hua
collection PubMed
description Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer. In cancer, the oxidative phosphorylation metabolic pathway is converted into the glycolytic pathway in order to meet the growth requirements of cancer cells, thereby creating a microenvironment that promotes cancer progression. The precise mechanism of glucose metabolism in cancer cells is still unknown, but it is thought to involve the aberrant levels of metabolic enzymes, the influence of the tumor microenvironment (TME), and the activation of tumor-promoting signaling pathways. It is suggested that glucose metabolism is strongly linked to cancer progression because it provides energy to cancer cells and interferes with antitumor drug pharmacodynamics. Therefore, it is critical to unravel the mechanism of glucose metabolism in tumors in order to gain a better understanding of tumorigenesis and to lay the groundwork for future research into the identification of novel diagnostic markers and therapeutic targets for cancer treatment. Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, multiple components, and less toxic side effects and has unique advantages in tumor treatment. In recent years, researchers have found that a variety of Chinese medicine monomers and compound recipes play an antitumor role by interfering with the reprogramming of tumor metabolism. The underlying mechanisms of metabolism reprogramming of tumor cells and the role of TCM in regulating glucose metabolism are reviewed in this study, so as to provide a new idea for antitumor research in Chinese medicine.
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spelling pubmed-95867382022-10-22 Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine Lai, Gui-hua Wang, Fei Nie, Duo-rui Lei, Shu-jun Wu, Zhuo-jun Cao, Jian-xiong Tang, Lan-lan Evid Based Complement Alternat Med Review Article Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer. In cancer, the oxidative phosphorylation metabolic pathway is converted into the glycolytic pathway in order to meet the growth requirements of cancer cells, thereby creating a microenvironment that promotes cancer progression. The precise mechanism of glucose metabolism in cancer cells is still unknown, but it is thought to involve the aberrant levels of metabolic enzymes, the influence of the tumor microenvironment (TME), and the activation of tumor-promoting signaling pathways. It is suggested that glucose metabolism is strongly linked to cancer progression because it provides energy to cancer cells and interferes with antitumor drug pharmacodynamics. Therefore, it is critical to unravel the mechanism of glucose metabolism in tumors in order to gain a better understanding of tumorigenesis and to lay the groundwork for future research into the identification of novel diagnostic markers and therapeutic targets for cancer treatment. Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, multiple components, and less toxic side effects and has unique advantages in tumor treatment. In recent years, researchers have found that a variety of Chinese medicine monomers and compound recipes play an antitumor role by interfering with the reprogramming of tumor metabolism. The underlying mechanisms of metabolism reprogramming of tumor cells and the role of TCM in regulating glucose metabolism are reviewed in this study, so as to provide a new idea for antitumor research in Chinese medicine. Hindawi 2022-10-14 /pmc/articles/PMC9586738/ /pubmed/36276846 http://dx.doi.org/10.1155/2022/2192654 Text en Copyright © 2022 Gui-hua Lai et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lai, Gui-hua
Wang, Fei
Nie, Duo-rui
Lei, Shu-jun
Wu, Zhuo-jun
Cao, Jian-xiong
Tang, Lan-lan
Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine
title Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine
title_full Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine
title_fullStr Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine
title_full_unstemmed Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine
title_short Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine
title_sort correlation of glucose metabolism with cancer and intervention with traditional chinese medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586738/
https://www.ncbi.nlm.nih.gov/pubmed/36276846
http://dx.doi.org/10.1155/2022/2192654
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