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Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine
Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586738/ https://www.ncbi.nlm.nih.gov/pubmed/36276846 http://dx.doi.org/10.1155/2022/2192654 |
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author | Lai, Gui-hua Wang, Fei Nie, Duo-rui Lei, Shu-jun Wu, Zhuo-jun Cao, Jian-xiong Tang, Lan-lan |
author_facet | Lai, Gui-hua Wang, Fei Nie, Duo-rui Lei, Shu-jun Wu, Zhuo-jun Cao, Jian-xiong Tang, Lan-lan |
author_sort | Lai, Gui-hua |
collection | PubMed |
description | Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer. In cancer, the oxidative phosphorylation metabolic pathway is converted into the glycolytic pathway in order to meet the growth requirements of cancer cells, thereby creating a microenvironment that promotes cancer progression. The precise mechanism of glucose metabolism in cancer cells is still unknown, but it is thought to involve the aberrant levels of metabolic enzymes, the influence of the tumor microenvironment (TME), and the activation of tumor-promoting signaling pathways. It is suggested that glucose metabolism is strongly linked to cancer progression because it provides energy to cancer cells and interferes with antitumor drug pharmacodynamics. Therefore, it is critical to unravel the mechanism of glucose metabolism in tumors in order to gain a better understanding of tumorigenesis and to lay the groundwork for future research into the identification of novel diagnostic markers and therapeutic targets for cancer treatment. Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, multiple components, and less toxic side effects and has unique advantages in tumor treatment. In recent years, researchers have found that a variety of Chinese medicine monomers and compound recipes play an antitumor role by interfering with the reprogramming of tumor metabolism. The underlying mechanisms of metabolism reprogramming of tumor cells and the role of TCM in regulating glucose metabolism are reviewed in this study, so as to provide a new idea for antitumor research in Chinese medicine. |
format | Online Article Text |
id | pubmed-9586738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-95867382022-10-22 Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine Lai, Gui-hua Wang, Fei Nie, Duo-rui Lei, Shu-jun Wu, Zhuo-jun Cao, Jian-xiong Tang, Lan-lan Evid Based Complement Alternat Med Review Article Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer. In cancer, the oxidative phosphorylation metabolic pathway is converted into the glycolytic pathway in order to meet the growth requirements of cancer cells, thereby creating a microenvironment that promotes cancer progression. The precise mechanism of glucose metabolism in cancer cells is still unknown, but it is thought to involve the aberrant levels of metabolic enzymes, the influence of the tumor microenvironment (TME), and the activation of tumor-promoting signaling pathways. It is suggested that glucose metabolism is strongly linked to cancer progression because it provides energy to cancer cells and interferes with antitumor drug pharmacodynamics. Therefore, it is critical to unravel the mechanism of glucose metabolism in tumors in order to gain a better understanding of tumorigenesis and to lay the groundwork for future research into the identification of novel diagnostic markers and therapeutic targets for cancer treatment. Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, multiple components, and less toxic side effects and has unique advantages in tumor treatment. In recent years, researchers have found that a variety of Chinese medicine monomers and compound recipes play an antitumor role by interfering with the reprogramming of tumor metabolism. The underlying mechanisms of metabolism reprogramming of tumor cells and the role of TCM in regulating glucose metabolism are reviewed in this study, so as to provide a new idea for antitumor research in Chinese medicine. Hindawi 2022-10-14 /pmc/articles/PMC9586738/ /pubmed/36276846 http://dx.doi.org/10.1155/2022/2192654 Text en Copyright © 2022 Gui-hua Lai et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lai, Gui-hua Wang, Fei Nie, Duo-rui Lei, Shu-jun Wu, Zhuo-jun Cao, Jian-xiong Tang, Lan-lan Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine |
title | Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine |
title_full | Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine |
title_fullStr | Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine |
title_full_unstemmed | Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine |
title_short | Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine |
title_sort | correlation of glucose metabolism with cancer and intervention with traditional chinese medicine |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586738/ https://www.ncbi.nlm.nih.gov/pubmed/36276846 http://dx.doi.org/10.1155/2022/2192654 |
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