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Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke

Ischemic stroke, which occurs following blockage of the blood supply to the brain, is a leading cause of death worldwide. Its main cause is atherosclerosis, a disease of the arteries characterized by the deposition of plaques of fatty material on the inner artery walls. Multiple proteins involved in...

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Autores principales: Zhang, Shuang, Huang, Shuchun, Hu, Dingju, Jiang, Fenglong, Lv, Yanli, Liu, Guoqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586817/
https://www.ncbi.nlm.nih.gov/pubmed/36313479
http://dx.doi.org/10.1155/2022/3328574
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author Zhang, Shuang
Huang, Shuchun
Hu, Dingju
Jiang, Fenglong
Lv, Yanli
Liu, Guoqi
author_facet Zhang, Shuang
Huang, Shuchun
Hu, Dingju
Jiang, Fenglong
Lv, Yanli
Liu, Guoqi
author_sort Zhang, Shuang
collection PubMed
description Ischemic stroke, which occurs following blockage of the blood supply to the brain, is a leading cause of death worldwide. Its main cause is atherosclerosis, a disease of the arteries characterized by the deposition of plaques of fatty material on the inner artery walls. Multiple proteins involved in the inflammation response have been identified as diagnosing biomarkers of ischemic stroke. One of these is lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an enzyme that can hydrolyze circulating oxidized phospholipids, generating proinflammatory lysophosphatidylcholine and promoting the development of atherosclerosis. In the last two decades, a number of studies have revealed that both the concentration and the activity of Lp-PLA(2) are independent biomarkers of ischemic stroke. The US Food and Drug Administration (FDA) has approved two tests to determine Lp-PLA(2) mass and activity for predicting stroke. In this review, we summarize the biological properties of Lp-PLA(2), the detection sensitivity and limitations of Lp-PLA(2) measurement, the clinical significance and association of Lp-PLA(2) in ischemic stroke, and the prospects of therapeutic inhibition of Lp-PLA(2) as an intervention and treatment.
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spelling pubmed-95868172022-10-28 Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke Zhang, Shuang Huang, Shuchun Hu, Dingju Jiang, Fenglong Lv, Yanli Liu, Guoqi Cardiovasc Ther Review Article Ischemic stroke, which occurs following blockage of the blood supply to the brain, is a leading cause of death worldwide. Its main cause is atherosclerosis, a disease of the arteries characterized by the deposition of plaques of fatty material on the inner artery walls. Multiple proteins involved in the inflammation response have been identified as diagnosing biomarkers of ischemic stroke. One of these is lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an enzyme that can hydrolyze circulating oxidized phospholipids, generating proinflammatory lysophosphatidylcholine and promoting the development of atherosclerosis. In the last two decades, a number of studies have revealed that both the concentration and the activity of Lp-PLA(2) are independent biomarkers of ischemic stroke. The US Food and Drug Administration (FDA) has approved two tests to determine Lp-PLA(2) mass and activity for predicting stroke. In this review, we summarize the biological properties of Lp-PLA(2), the detection sensitivity and limitations of Lp-PLA(2) measurement, the clinical significance and association of Lp-PLA(2) in ischemic stroke, and the prospects of therapeutic inhibition of Lp-PLA(2) as an intervention and treatment. Hindawi 2022-10-14 /pmc/articles/PMC9586817/ /pubmed/36313479 http://dx.doi.org/10.1155/2022/3328574 Text en Copyright © 2022 Shuang Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Shuang
Huang, Shuchun
Hu, Dingju
Jiang, Fenglong
Lv, Yanli
Liu, Guoqi
Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke
title Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke
title_full Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke
title_fullStr Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke
title_full_unstemmed Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke
title_short Biological Properties and Clinical Significance of Lipoprotein-Associated Phospholipase A(2) in Ischemic Stroke
title_sort biological properties and clinical significance of lipoprotein-associated phospholipase a(2) in ischemic stroke
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586817/
https://www.ncbi.nlm.nih.gov/pubmed/36313479
http://dx.doi.org/10.1155/2022/3328574
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