Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition

Oesophageal adenocarcinoma (OAC) patients show poor survival rates and there are few targeted molecular therapies available. However, components of the receptor tyrosine kinase (RTK) driven pathways are commonly mutated in OAC, typified by high frequency amplifications of the RTK ERBB2. ERBB2 can be...

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Detalles Bibliográficos
Autores principales: Ogden, Samuel, Carys, Kashmala, Ahmed, Ibrahim, Bruce, Jason, Sharrocks, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586873/
https://www.ncbi.nlm.nih.gov/pubmed/36153371
http://dx.doi.org/10.1038/s41388-022-02465-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586873/
https://www.ncbi.nlm.nih.gov/pubmed/36153371
http://dx.doi.org/10.1038/s41388-022-02465-w

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