Cargando…

Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study

AIM: This study aimed to evaluate clinically significant sex differences that could have an effect on the choice of treatment and outcomes of urinary tract infection (UTI) in aged 80 and over hospitalized patients with community-acquired UTI. METHODS: This was a prospective study of 161 patients age...

Descripción completa

Detalles Bibliográficos
Autores principales: López-Cruz, Ian, Esparcia, Ana, Madrazo, Manuel, Alberola, Juan, Eiros, José María, Artero, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586905/
https://www.ncbi.nlm.nih.gov/pubmed/36281411
http://dx.doi.org/10.1016/j.heliyon.2022.e11131
_version_ 1784813787655700480
author López-Cruz, Ian
Esparcia, Ana
Madrazo, Manuel
Alberola, Juan
Eiros, José María
Artero, Arturo
author_facet López-Cruz, Ian
Esparcia, Ana
Madrazo, Manuel
Alberola, Juan
Eiros, José María
Artero, Arturo
author_sort López-Cruz, Ian
collection PubMed
description AIM: This study aimed to evaluate clinically significant sex differences that could have an effect on the choice of treatment and outcomes of urinary tract infection (UTI) in aged 80 and over hospitalized patients with community-acquired UTI. METHODS: This was a prospective study of 161 patients aged 80 and over admitted to hospital with community-acquired UTI. Epidemiological, clinical, laboratory and microbiologic variables were compared between both sexes. Multivariate analysis was performed using logistic regression to determine the variables independently associated with sex. RESULTS: In a population of 91 (56.52%) women and 70 (43.48%) men, aged 80 and over, we found that women were more likely to have cognitive impairment (p = 0.035) and less likely to have chronic obstructive pulmonary disease (COPD) (p = 0.006) and indwelling urinary catheter (p < 0.001) than men. Levels of creatinine were higher in men than in women (p = 0.008). Septic shock at presentation was more frequent in the male group (p = 0.043). Men had a higher rate of polymicrobial infection (p = 0.035) and Pseudomonas aeruginosa infection (p = 0.003). Factors independently associated with sex by multivariate analysis were septic shock, cognitive impairment, COPD and indwelling urinary catheter. CONCLUSION: Men aged 80 and over with community-acquired UTI had more septic shock at admission to hospital and higher rates of indwelling urinary catheter, while women had more cognitive impairment. There were no differences in outcomes between sexes.
format Online
Article
Text
id pubmed-9586905
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-95869052022-10-23 Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study López-Cruz, Ian Esparcia, Ana Madrazo, Manuel Alberola, Juan Eiros, José María Artero, Arturo Heliyon Research Article AIM: This study aimed to evaluate clinically significant sex differences that could have an effect on the choice of treatment and outcomes of urinary tract infection (UTI) in aged 80 and over hospitalized patients with community-acquired UTI. METHODS: This was a prospective study of 161 patients aged 80 and over admitted to hospital with community-acquired UTI. Epidemiological, clinical, laboratory and microbiologic variables were compared between both sexes. Multivariate analysis was performed using logistic regression to determine the variables independently associated with sex. RESULTS: In a population of 91 (56.52%) women and 70 (43.48%) men, aged 80 and over, we found that women were more likely to have cognitive impairment (p = 0.035) and less likely to have chronic obstructive pulmonary disease (COPD) (p = 0.006) and indwelling urinary catheter (p < 0.001) than men. Levels of creatinine were higher in men than in women (p = 0.008). Septic shock at presentation was more frequent in the male group (p = 0.043). Men had a higher rate of polymicrobial infection (p = 0.035) and Pseudomonas aeruginosa infection (p = 0.003). Factors independently associated with sex by multivariate analysis were septic shock, cognitive impairment, COPD and indwelling urinary catheter. CONCLUSION: Men aged 80 and over with community-acquired UTI had more septic shock at admission to hospital and higher rates of indwelling urinary catheter, while women had more cognitive impairment. There were no differences in outcomes between sexes. Elsevier 2022-10-18 /pmc/articles/PMC9586905/ /pubmed/36281411 http://dx.doi.org/10.1016/j.heliyon.2022.e11131 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
López-Cruz, Ian
Esparcia, Ana
Madrazo, Manuel
Alberola, Juan
Eiros, José María
Artero, Arturo
Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study
title Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study
title_full Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study
title_fullStr Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study
title_full_unstemmed Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study
title_short Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study
title_sort sex differences in aged 80 and over hospitalized patients with community-acquired uti: a prospective observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586905/
https://www.ncbi.nlm.nih.gov/pubmed/36281411
http://dx.doi.org/10.1016/j.heliyon.2022.e11131
work_keys_str_mv AT lopezcruzian sexdifferencesinaged80andoverhospitalizedpatientswithcommunityacquiredutiaprospectiveobservationalstudy
AT esparciaana sexdifferencesinaged80andoverhospitalizedpatientswithcommunityacquiredutiaprospectiveobservationalstudy
AT madrazomanuel sexdifferencesinaged80andoverhospitalizedpatientswithcommunityacquiredutiaprospectiveobservationalstudy
AT alberolajuan sexdifferencesinaged80andoverhospitalizedpatientswithcommunityacquiredutiaprospectiveobservationalstudy
AT eirosjosemaria sexdifferencesinaged80andoverhospitalizedpatientswithcommunityacquiredutiaprospectiveobservationalstudy
AT arteroarturo sexdifferencesinaged80andoverhospitalizedpatientswithcommunityacquiredutiaprospectiveobservationalstudy