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Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study
AIM: This study aimed to evaluate clinically significant sex differences that could have an effect on the choice of treatment and outcomes of urinary tract infection (UTI) in aged 80 and over hospitalized patients with community-acquired UTI. METHODS: This was a prospective study of 161 patients age...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586905/ https://www.ncbi.nlm.nih.gov/pubmed/36281411 http://dx.doi.org/10.1016/j.heliyon.2022.e11131 |
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author | López-Cruz, Ian Esparcia, Ana Madrazo, Manuel Alberola, Juan Eiros, José María Artero, Arturo |
author_facet | López-Cruz, Ian Esparcia, Ana Madrazo, Manuel Alberola, Juan Eiros, José María Artero, Arturo |
author_sort | López-Cruz, Ian |
collection | PubMed |
description | AIM: This study aimed to evaluate clinically significant sex differences that could have an effect on the choice of treatment and outcomes of urinary tract infection (UTI) in aged 80 and over hospitalized patients with community-acquired UTI. METHODS: This was a prospective study of 161 patients aged 80 and over admitted to hospital with community-acquired UTI. Epidemiological, clinical, laboratory and microbiologic variables were compared between both sexes. Multivariate analysis was performed using logistic regression to determine the variables independently associated with sex. RESULTS: In a population of 91 (56.52%) women and 70 (43.48%) men, aged 80 and over, we found that women were more likely to have cognitive impairment (p = 0.035) and less likely to have chronic obstructive pulmonary disease (COPD) (p = 0.006) and indwelling urinary catheter (p < 0.001) than men. Levels of creatinine were higher in men than in women (p = 0.008). Septic shock at presentation was more frequent in the male group (p = 0.043). Men had a higher rate of polymicrobial infection (p = 0.035) and Pseudomonas aeruginosa infection (p = 0.003). Factors independently associated with sex by multivariate analysis were septic shock, cognitive impairment, COPD and indwelling urinary catheter. CONCLUSION: Men aged 80 and over with community-acquired UTI had more septic shock at admission to hospital and higher rates of indwelling urinary catheter, while women had more cognitive impairment. There were no differences in outcomes between sexes. |
format | Online Article Text |
id | pubmed-9586905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-95869052022-10-23 Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study López-Cruz, Ian Esparcia, Ana Madrazo, Manuel Alberola, Juan Eiros, José María Artero, Arturo Heliyon Research Article AIM: This study aimed to evaluate clinically significant sex differences that could have an effect on the choice of treatment and outcomes of urinary tract infection (UTI) in aged 80 and over hospitalized patients with community-acquired UTI. METHODS: This was a prospective study of 161 patients aged 80 and over admitted to hospital with community-acquired UTI. Epidemiological, clinical, laboratory and microbiologic variables were compared between both sexes. Multivariate analysis was performed using logistic regression to determine the variables independently associated with sex. RESULTS: In a population of 91 (56.52%) women and 70 (43.48%) men, aged 80 and over, we found that women were more likely to have cognitive impairment (p = 0.035) and less likely to have chronic obstructive pulmonary disease (COPD) (p = 0.006) and indwelling urinary catheter (p < 0.001) than men. Levels of creatinine were higher in men than in women (p = 0.008). Septic shock at presentation was more frequent in the male group (p = 0.043). Men had a higher rate of polymicrobial infection (p = 0.035) and Pseudomonas aeruginosa infection (p = 0.003). Factors independently associated with sex by multivariate analysis were septic shock, cognitive impairment, COPD and indwelling urinary catheter. CONCLUSION: Men aged 80 and over with community-acquired UTI had more septic shock at admission to hospital and higher rates of indwelling urinary catheter, while women had more cognitive impairment. There were no differences in outcomes between sexes. Elsevier 2022-10-18 /pmc/articles/PMC9586905/ /pubmed/36281411 http://dx.doi.org/10.1016/j.heliyon.2022.e11131 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article López-Cruz, Ian Esparcia, Ana Madrazo, Manuel Alberola, Juan Eiros, José María Artero, Arturo Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study |
title | Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study |
title_full | Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study |
title_fullStr | Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study |
title_full_unstemmed | Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study |
title_short | Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study |
title_sort | sex differences in aged 80 and over hospitalized patients with community-acquired uti: a prospective observational study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586905/ https://www.ncbi.nlm.nih.gov/pubmed/36281411 http://dx.doi.org/10.1016/j.heliyon.2022.e11131 |
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