Picomolar fluorescent probes for compound affinity determination to carbonic anhydrase IX expressed in live cancer cells

Numerous human cancers, especially hypoxic solid tumors, express carbonic anhydrase IX (CAIX), a transmembrane protein with its catalytic domain located in the extracellular space. CAIX acidifies the tumor microenvironment, promotes metastases and invasiveness, and is therefore considered a promisin...

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Detalles Bibliográficos
Autores principales: Matulienė, Jurgita, Žvinys, Gediminas, Petrauskas, Vytautas, Kvietkauskaitė, Agnė, Zakšauskas, Audrius, Shubin, Kirill, Zubrienė, Asta, Baranauskienė, Lina, Kačenauskaitė, Lina, Kopanchuk, Sergei, Veiksina, Santa, Paketurytė-Latvė, Vaida, Smirnovienė, Joana, Juozapaitienė, Vaida, Mickevičiūtė, Aurelija, Michailovienė, Vilma, Jachno, Jelena, Stravinskienė, Dovilė, Sližienė, Aistė, Petrošiūtė, Agnė, Becker, Holger M., Kazokaitė-Adomaitienė, Justina, Yaromina, Ala, Čapkauskaitė, Edita, Rinken, Ago, Dudutienė, Virginija, Dubois, Ludwig J, Matulis, Daumantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586938/
https://www.ncbi.nlm.nih.gov/pubmed/36271018
http://dx.doi.org/10.1038/s41598-022-22436-1

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