Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane

Polymyxins are last-resort antibiotics with potent activity against multi-drug resistant pathogens. They interact with lipopolysaccharide (LPS) in bacterial membranes, but mechanistic details at the molecular level remain unclear. Here, we characterize the interaction of polymyxins with native, LPS-...

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Detalles Bibliográficos
Autores principales: Manioglu, Selen, Modaresi, Seyed Majed, Ritzmann, Noah, Thoma, Johannes, Overall, Sarah A., Harms, Alexander, Upert, Gregory, Luther, Anatol, Barnes, Alexander B., Obrecht, Daniel, Müller, Daniel J., Hiller, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587031/
https://www.ncbi.nlm.nih.gov/pubmed/36271003
http://dx.doi.org/10.1038/s41467-022-33838-0

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