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Mapping periplasmic binding protein oligosaccharide recognition with neutron crystallography

Numerous studies have shown how periplasmic binding proteins (PBPs) bind substrates with exquisite specificity, even distinguishing between sugar epimers and anomers, or structurally similar ions. Yet, marked substrate promiscuity is also a feature encoded in some PBPs. Except for three sub-Ångström...

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Detalles Bibliográficos
Autores principales: Shukla, Shantanu, Myles, Dean A., Cuneo, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587032/
https://www.ncbi.nlm.nih.gov/pubmed/36271099
http://dx.doi.org/10.1038/s41598-022-20542-8