The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model

The number of sugar-sweetened beverages consumed per day has been associated with an increased risk of acute rheumatic fever, an autoimmune disease triggered by superficial Streptococcus pyogenes infection. To explore if there could be a biological basis for this association, we used a mouse model o...

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Autores principales: Hashimi, Farina Nor, Bennett, Julie, Baker, Michael G., Moreland, Nicole J., Merry, Troy L., Loh, Jacelyn M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587037/
https://www.ncbi.nlm.nih.gov/pubmed/36271250
http://dx.doi.org/10.1038/s41598-022-22648-5
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author Hashimi, Farina Nor
Bennett, Julie
Baker, Michael G.
Moreland, Nicole J.
Merry, Troy L.
Loh, Jacelyn M. S.
author_facet Hashimi, Farina Nor
Bennett, Julie
Baker, Michael G.
Moreland, Nicole J.
Merry, Troy L.
Loh, Jacelyn M. S.
author_sort Hashimi, Farina Nor
collection PubMed
description The number of sugar-sweetened beverages consumed per day has been associated with an increased risk of acute rheumatic fever, an autoimmune disease triggered by superficial Streptococcus pyogenes infection. To explore if there could be a biological basis for this association, we used a mouse model of S. pyogenes nasopharyngeal colonisation combined with a dietary intervention. We observed an increased bacterial load in the nasopharynx of mice receiving sucrose drinking water post-infection, suggesting that high sucrose intake promotes S. pyogenes growth and/or survival. This provides new insight into the potential biological basis behind the association seen in humans.
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spelling pubmed-95870372022-10-23 The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model Hashimi, Farina Nor Bennett, Julie Baker, Michael G. Moreland, Nicole J. Merry, Troy L. Loh, Jacelyn M. S. Sci Rep Article The number of sugar-sweetened beverages consumed per day has been associated with an increased risk of acute rheumatic fever, an autoimmune disease triggered by superficial Streptococcus pyogenes infection. To explore if there could be a biological basis for this association, we used a mouse model of S. pyogenes nasopharyngeal colonisation combined with a dietary intervention. We observed an increased bacterial load in the nasopharynx of mice receiving sucrose drinking water post-infection, suggesting that high sucrose intake promotes S. pyogenes growth and/or survival. This provides new insight into the potential biological basis behind the association seen in humans. Nature Publishing Group UK 2022-10-21 /pmc/articles/PMC9587037/ /pubmed/36271250 http://dx.doi.org/10.1038/s41598-022-22648-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hashimi, Farina Nor
Bennett, Julie
Baker, Michael G.
Moreland, Nicole J.
Merry, Troy L.
Loh, Jacelyn M. S.
The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model
title The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model
title_full The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model
title_fullStr The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model
title_full_unstemmed The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model
title_short The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model
title_sort effects of sugar in drinking water on streptococcus pyogenes colonisation in a murine nasopharyngeal infection model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587037/
https://www.ncbi.nlm.nih.gov/pubmed/36271250
http://dx.doi.org/10.1038/s41598-022-22648-5
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