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Organs-on-chip technology: a tool to tackle genetic kidney diseases

Chronic kidney disease (CKD) is a major healthcare burden that takes a toll on the quality of life of many patients. Emerging evidence indicates that a substantial proportion of these patients carry a genetic defect that contributes to their disease. Any effort to reduce the percentage of patients w...

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Autores principales: G. Valverde, Marta, Faria, João, Sendino Garví, Elena, Janssen, Manoe J., Masereeuw, Rosalinde, Mihăilă, Silvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587109/
https://www.ncbi.nlm.nih.gov/pubmed/35286457
http://dx.doi.org/10.1007/s00467-022-05508-2
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author G. Valverde, Marta
Faria, João
Sendino Garví, Elena
Janssen, Manoe J.
Masereeuw, Rosalinde
Mihăilă, Silvia M.
author_facet G. Valverde, Marta
Faria, João
Sendino Garví, Elena
Janssen, Manoe J.
Masereeuw, Rosalinde
Mihăilă, Silvia M.
author_sort G. Valverde, Marta
collection PubMed
description Chronic kidney disease (CKD) is a major healthcare burden that takes a toll on the quality of life of many patients. Emerging evidence indicates that a substantial proportion of these patients carry a genetic defect that contributes to their disease. Any effort to reduce the percentage of patients with a diagnosis of nephropathy heading towards kidney replacement therapies should therefore be encouraged. Besides early genetic screenings and registries, in vitro systems that mimic the complexity and pathophysiological aspects of the disease could advance the screening for targeted and personalized therapies. In this regard, the use of patient-derived cell lines, as well as the generation of disease-specific cell lines via gene editing and stem cell technologies, have significantly improved our understanding of the molecular mechanisms underlying inherited kidney diseases. Furthermore, organs-on-chip technology holds great potential as it can emulate tissue and organ functions that are not found in other, more simple, in vitro models. The personalized nature of the chips, together with physiologically relevant read-outs, provide new opportunities for patient-specific assessment, as well as personalized strategies for treatment. In this review, we summarize the major kidney-on-chip (KOC) configurations and present the most recent studies on the in vitro representation of genetic kidney diseases using KOC-driven strategies.
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spelling pubmed-95871092022-10-23 Organs-on-chip technology: a tool to tackle genetic kidney diseases G. Valverde, Marta Faria, João Sendino Garví, Elena Janssen, Manoe J. Masereeuw, Rosalinde Mihăilă, Silvia M. Pediatr Nephrol Review Chronic kidney disease (CKD) is a major healthcare burden that takes a toll on the quality of life of many patients. Emerging evidence indicates that a substantial proportion of these patients carry a genetic defect that contributes to their disease. Any effort to reduce the percentage of patients with a diagnosis of nephropathy heading towards kidney replacement therapies should therefore be encouraged. Besides early genetic screenings and registries, in vitro systems that mimic the complexity and pathophysiological aspects of the disease could advance the screening for targeted and personalized therapies. In this regard, the use of patient-derived cell lines, as well as the generation of disease-specific cell lines via gene editing and stem cell technologies, have significantly improved our understanding of the molecular mechanisms underlying inherited kidney diseases. Furthermore, organs-on-chip technology holds great potential as it can emulate tissue and organ functions that are not found in other, more simple, in vitro models. The personalized nature of the chips, together with physiologically relevant read-outs, provide new opportunities for patient-specific assessment, as well as personalized strategies for treatment. In this review, we summarize the major kidney-on-chip (KOC) configurations and present the most recent studies on the in vitro representation of genetic kidney diseases using KOC-driven strategies. Springer Berlin Heidelberg 2022-03-14 2022 /pmc/articles/PMC9587109/ /pubmed/35286457 http://dx.doi.org/10.1007/s00467-022-05508-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
G. Valverde, Marta
Faria, João
Sendino Garví, Elena
Janssen, Manoe J.
Masereeuw, Rosalinde
Mihăilă, Silvia M.
Organs-on-chip technology: a tool to tackle genetic kidney diseases
title Organs-on-chip technology: a tool to tackle genetic kidney diseases
title_full Organs-on-chip technology: a tool to tackle genetic kidney diseases
title_fullStr Organs-on-chip technology: a tool to tackle genetic kidney diseases
title_full_unstemmed Organs-on-chip technology: a tool to tackle genetic kidney diseases
title_short Organs-on-chip technology: a tool to tackle genetic kidney diseases
title_sort organs-on-chip technology: a tool to tackle genetic kidney diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587109/
https://www.ncbi.nlm.nih.gov/pubmed/35286457
http://dx.doi.org/10.1007/s00467-022-05508-2
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