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Effects of Tafluprost on Ocular Blood Flow
Increasing evidence indicates that improving ocular blood flow (OBF) can be a therapeutic direction for glaucoma therapy. Tafluprost, a prostaglandin analogue which lowers the intraocular pressure (IOP), has been shown to improve OBF in animals and humans. Several animal experiments showed that topi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587142/ https://www.ncbi.nlm.nih.gov/pubmed/36109465 http://dx.doi.org/10.1007/s40123-022-00566-z |
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author | Zhang, Xinyue Zhou, Xiaoyu Zhao, Yang Yang, Xiang Zhou, Dengming Chen, Baihua Duan, Xuanchu |
author_facet | Zhang, Xinyue Zhou, Xiaoyu Zhao, Yang Yang, Xiang Zhou, Dengming Chen, Baihua Duan, Xuanchu |
author_sort | Zhang, Xinyue |
collection | PubMed |
description | Increasing evidence indicates that improving ocular blood flow (OBF) can be a therapeutic direction for glaucoma therapy. Tafluprost, a prostaglandin analogue which lowers the intraocular pressure (IOP), has been shown to improve OBF in animals and humans. Several animal experiments showed that topical tafluprost significantly increased optic nerve head and retinal blood flow. Clinical trials also showed a beneficial effect of tafluprost on optic nerve head and macula blood flow, and a good ocular pulse amplitude-lowering effect. But, there are still a few conflicting results. Overall, tafluprost seems to have a beneficial effect on OBF, and the positive effect is probably independent from its IOP-lowering effect, which also is expected to improve OBF. Moreover, reducing the intracellular free Ca(2+) concentration may be a possible mechanism of tafluprost’s effect on OBF. More well-designed studies are required to reveal the truth. |
format | Online Article Text |
id | pubmed-9587142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-95871422022-11-29 Effects of Tafluprost on Ocular Blood Flow Zhang, Xinyue Zhou, Xiaoyu Zhao, Yang Yang, Xiang Zhou, Dengming Chen, Baihua Duan, Xuanchu Ophthalmol Ther Review Increasing evidence indicates that improving ocular blood flow (OBF) can be a therapeutic direction for glaucoma therapy. Tafluprost, a prostaglandin analogue which lowers the intraocular pressure (IOP), has been shown to improve OBF in animals and humans. Several animal experiments showed that topical tafluprost significantly increased optic nerve head and retinal blood flow. Clinical trials also showed a beneficial effect of tafluprost on optic nerve head and macula blood flow, and a good ocular pulse amplitude-lowering effect. But, there are still a few conflicting results. Overall, tafluprost seems to have a beneficial effect on OBF, and the positive effect is probably independent from its IOP-lowering effect, which also is expected to improve OBF. Moreover, reducing the intracellular free Ca(2+) concentration may be a possible mechanism of tafluprost’s effect on OBF. More well-designed studies are required to reveal the truth. Springer Healthcare 2022-09-15 2022-12 /pmc/articles/PMC9587142/ /pubmed/36109465 http://dx.doi.org/10.1007/s40123-022-00566-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Review Zhang, Xinyue Zhou, Xiaoyu Zhao, Yang Yang, Xiang Zhou, Dengming Chen, Baihua Duan, Xuanchu Effects of Tafluprost on Ocular Blood Flow |
title | Effects of Tafluprost on Ocular Blood Flow |
title_full | Effects of Tafluprost on Ocular Blood Flow |
title_fullStr | Effects of Tafluprost on Ocular Blood Flow |
title_full_unstemmed | Effects of Tafluprost on Ocular Blood Flow |
title_short | Effects of Tafluprost on Ocular Blood Flow |
title_sort | effects of tafluprost on ocular blood flow |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587142/ https://www.ncbi.nlm.nih.gov/pubmed/36109465 http://dx.doi.org/10.1007/s40123-022-00566-z |
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