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Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice
The nucleus accumbens (NAc) is critical in mediating reward seeking and is also involved in negative emotion processing, but the cellular and circuitry mechanisms underlying such opposing behaviors remain elusive. Here, using the recently developed AAV1-mediated anterograde transsynaptic tagging tec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587247/ https://www.ncbi.nlm.nih.gov/pubmed/36271048 http://dx.doi.org/10.1038/s41467-022-33843-3 |
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author | Zhou, Kuikui Xu, Hua Lu, Shanshan Jiang, Shaolei Hou, Guoqiang Deng, Xiaofei He, Miao Zhu, Yingjie |
author_facet | Zhou, Kuikui Xu, Hua Lu, Shanshan Jiang, Shaolei Hou, Guoqiang Deng, Xiaofei He, Miao Zhu, Yingjie |
author_sort | Zhou, Kuikui |
collection | PubMed |
description | The nucleus accumbens (NAc) is critical in mediating reward seeking and is also involved in negative emotion processing, but the cellular and circuitry mechanisms underlying such opposing behaviors remain elusive. Here, using the recently developed AAV1-mediated anterograde transsynaptic tagging technique in mice, we show that NAc neurons receiving basolateral amygdala inputs (NAc(BLA)) promote positive reinforcement via disinhibiting dopamine neurons in the ventral tegmental area (VTA). In contrast, NAc neurons receiving paraventricular thalamic inputs (NAc(PVT)) innervate GABAergic neurons in the lateral hypothalamus (LH) and mediate aversion. Silencing the synaptic output of NAc(BLA) neurons impairs reward seeking behavior, while silencing of NAc(PVT) or NAc(PVT)→LH pathway abolishes aversive symptoms of opiate withdrawal. Our results elucidate the afferent-specific circuit architecture of the NAc in controlling reward and aversion. |
format | Online Article Text |
id | pubmed-9587247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95872472022-10-23 Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice Zhou, Kuikui Xu, Hua Lu, Shanshan Jiang, Shaolei Hou, Guoqiang Deng, Xiaofei He, Miao Zhu, Yingjie Nat Commun Article The nucleus accumbens (NAc) is critical in mediating reward seeking and is also involved in negative emotion processing, but the cellular and circuitry mechanisms underlying such opposing behaviors remain elusive. Here, using the recently developed AAV1-mediated anterograde transsynaptic tagging technique in mice, we show that NAc neurons receiving basolateral amygdala inputs (NAc(BLA)) promote positive reinforcement via disinhibiting dopamine neurons in the ventral tegmental area (VTA). In contrast, NAc neurons receiving paraventricular thalamic inputs (NAc(PVT)) innervate GABAergic neurons in the lateral hypothalamus (LH) and mediate aversion. Silencing the synaptic output of NAc(BLA) neurons impairs reward seeking behavior, while silencing of NAc(PVT) or NAc(PVT)→LH pathway abolishes aversive symptoms of opiate withdrawal. Our results elucidate the afferent-specific circuit architecture of the NAc in controlling reward and aversion. Nature Publishing Group UK 2022-10-21 /pmc/articles/PMC9587247/ /pubmed/36271048 http://dx.doi.org/10.1038/s41467-022-33843-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhou, Kuikui Xu, Hua Lu, Shanshan Jiang, Shaolei Hou, Guoqiang Deng, Xiaofei He, Miao Zhu, Yingjie Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice |
title | Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice |
title_full | Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice |
title_fullStr | Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice |
title_full_unstemmed | Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice |
title_short | Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice |
title_sort | reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587247/ https://www.ncbi.nlm.nih.gov/pubmed/36271048 http://dx.doi.org/10.1038/s41467-022-33843-3 |
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