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Contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention

Toxicity resulting from retained contrast media may cause adverse cardiovascular outcomes (e.g., heart failure and cardiogenic shock) for dialysis patients. However, the association between the administered contrast volume and outcomes of dialysis patients after percutaneous coronary intervention (P...

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Autores principales: Kuno, Toshiki, Numasawa, Yohei, Shoji, Satoshi, Ueda, Ikuko, Suzuki, Masahiro, Noma, Shigetaka, Fukuda, Keiichi, Kohsaka, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587255/
https://www.ncbi.nlm.nih.gov/pubmed/36271104
http://dx.doi.org/10.1038/s41598-022-21815-y
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author Kuno, Toshiki
Numasawa, Yohei
Shoji, Satoshi
Ueda, Ikuko
Suzuki, Masahiro
Noma, Shigetaka
Fukuda, Keiichi
Kohsaka, Shun
author_facet Kuno, Toshiki
Numasawa, Yohei
Shoji, Satoshi
Ueda, Ikuko
Suzuki, Masahiro
Noma, Shigetaka
Fukuda, Keiichi
Kohsaka, Shun
author_sort Kuno, Toshiki
collection PubMed
description Toxicity resulting from retained contrast media may cause adverse cardiovascular outcomes (e.g., heart failure and cardiogenic shock) for dialysis patients. However, the association between the administered contrast volume and outcomes of dialysis patients after percutaneous coronary intervention (PCI) has not been sufficiently investigated. We evaluated 953 consecutive dialysis patients (age, 67.9 ± 9.9 years; 30.1% with acute coronary syndrome) who underwent PCI between September 2008 and March 2019. Patients were divided into two groups: those with a contrast volume ≥ 200 ml and those with a contrast volume < 200 ml. The cutoff was 200 ml because 100 ml increment of contrast volume is known to raise the risk of acute kidney injury, and 200 ml is more than the average volume used at most PCI centers. The primary endpoint was a composite of in-hospital death, post-PCI cardiogenic shock and post-PCI heart failure. A multivariable logistic regression model and smooth spline curve were constructed to assess the association between contrast volume and the primary endpoint. The median contrast volume was 157 ml (interquartile range, 115–210 ml). The overall primary endpoint incidence was 6.8% (N = 65). A contrast volume ≥ 200 ml was associated with a higher risk of the primary endpoint (odds ratio 2.91; 95% confidence interval 1.42–6.05; P = 0.004). The smooth spline curve demonstrated a linear relationship between the contrast volume and primary endpoint. In conclusions, the contrast volume was associated with adverse in-hospital outcomes of dialysis patients undergoing PCI. Attention should be focused on the contrast volume used for dialysis patients undergoing PCI.
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spelling pubmed-95872552022-10-23 Contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention Kuno, Toshiki Numasawa, Yohei Shoji, Satoshi Ueda, Ikuko Suzuki, Masahiro Noma, Shigetaka Fukuda, Keiichi Kohsaka, Shun Sci Rep Article Toxicity resulting from retained contrast media may cause adverse cardiovascular outcomes (e.g., heart failure and cardiogenic shock) for dialysis patients. However, the association between the administered contrast volume and outcomes of dialysis patients after percutaneous coronary intervention (PCI) has not been sufficiently investigated. We evaluated 953 consecutive dialysis patients (age, 67.9 ± 9.9 years; 30.1% with acute coronary syndrome) who underwent PCI between September 2008 and March 2019. Patients were divided into two groups: those with a contrast volume ≥ 200 ml and those with a contrast volume < 200 ml. The cutoff was 200 ml because 100 ml increment of contrast volume is known to raise the risk of acute kidney injury, and 200 ml is more than the average volume used at most PCI centers. The primary endpoint was a composite of in-hospital death, post-PCI cardiogenic shock and post-PCI heart failure. A multivariable logistic regression model and smooth spline curve were constructed to assess the association between contrast volume and the primary endpoint. The median contrast volume was 157 ml (interquartile range, 115–210 ml). The overall primary endpoint incidence was 6.8% (N = 65). A contrast volume ≥ 200 ml was associated with a higher risk of the primary endpoint (odds ratio 2.91; 95% confidence interval 1.42–6.05; P = 0.004). The smooth spline curve demonstrated a linear relationship between the contrast volume and primary endpoint. In conclusions, the contrast volume was associated with adverse in-hospital outcomes of dialysis patients undergoing PCI. Attention should be focused on the contrast volume used for dialysis patients undergoing PCI. Nature Publishing Group UK 2022-10-21 /pmc/articles/PMC9587255/ /pubmed/36271104 http://dx.doi.org/10.1038/s41598-022-21815-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kuno, Toshiki
Numasawa, Yohei
Shoji, Satoshi
Ueda, Ikuko
Suzuki, Masahiro
Noma, Shigetaka
Fukuda, Keiichi
Kohsaka, Shun
Contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention
title Contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention
title_full Contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention
title_fullStr Contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention
title_full_unstemmed Contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention
title_short Contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention
title_sort contrast volume and in-hospital outcomes of dialysis patients undergoing percutaneous coronary intervention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587255/
https://www.ncbi.nlm.nih.gov/pubmed/36271104
http://dx.doi.org/10.1038/s41598-022-21815-y
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