Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment

Pheochromocytomas (PC) and paragangliomas (PG) are rare neuroendocrine tumors associated with autonomic nerves. Here we use single-nuclei RNA-seq and bulk-tissue gene-expression data to characterize the cellular composition of PCPG and normal adrenal tissues, refine tumor gene-expression subtypes an...

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Detalles Bibliográficos
Autores principales: Zethoven, Magnus, Martelotto, Luciano, Pattison, Andrew, Bowen, Blake, Balachander, Shiva, Flynn, Aidan, Rossello, Fernando J., Hogg, Annette, Miller, Julie A., Frysak, Zdenek, Grimmond, Sean, Fishbein, Lauren, Tischler, Arthur S., Gill, Anthony J., Hicks, Rodney J., Dahia, Patricia L. M., Clifton-Bligh, Roderick, Pacak, Karel, Tothill, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587261/
https://www.ncbi.nlm.nih.gov/pubmed/36271074
http://dx.doi.org/10.1038/s41467-022-34011-3

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