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DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Genetic variants in the DNA methyltransferase 3 A (DNMT3A) locus have been associated with inflammatory bowel disease (IBD). DNMT3A is part of the epigenetic machinery physiologically involved in DNA methylation. We show that DNMT3A plays a critical role in maintaining intestinal homeostasis and gut...

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Detalles Bibliográficos
Autores principales:	Fazio, Antonella, Bordoni, Dora, Kuiper, Jan W. P., Weber-Stiehl, Saskia, Stengel, Stephanie T., Arnold, Philipp, Ellinghaus, David, Ito, Go, Tran, Florian, Messner, Berith, Henning, Anna, Bernardes, Joana P., Häsler, Robert, Luzius, Anne, Imm, Simon, Hinrichsen, Finn, Franke, Andre, Huber, Samuel, Nikolaus, Susanna, Aden, Konrad, Schreiber, Stefan, Sommer, Felix, Natoli, Gioacchino, Mishra, Neha, Rosenstiel, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587301/ https://www.ncbi.nlm.nih.gov/pubmed/36271073 http://dx.doi.org/10.1038/s41467-022-33844-2

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