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Dopaminergic neurons are not a major Sonic hedgehog ligand source for striatal cholinergic or PV interneurons

A model was previously proposed that DA neurons provide SHH ligand to striatal interneurons, which in turn support the survival of DA neurons through the release of trophic factors such as Glial cell-derived neurotrophic factor (GDNF). However, some key clinical observations do not support this prop...

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Detalles Bibliográficos
Autores principales: Turcato, Flavia Correa, Wegman, Elliot, Lu, Tao, Ferguson, Nathan, Luo, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587326/
https://www.ncbi.nlm.nih.gov/pubmed/36281454
http://dx.doi.org/10.1016/j.isci.2022.105278