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The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine

The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of mul...

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Detalles Bibliográficos
Autores principales: Lawrence-Mills, Sara J., Hughes, David, Hezzell, Melanie J., Butler, Matthew, Neal, Chris, Foster, Rebecca R., Welsh, Gavin I., Finch, Natalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Balliere Tindall 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587354/
https://www.ncbi.nlm.nih.gov/pubmed/35654338
http://dx.doi.org/10.1016/j.tvjl.2022.105843
Descripción
Sumario:The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.