Cargando…

The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine

The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of mul...

Descripción completa

Detalles Bibliográficos
Autores principales: Lawrence-Mills, Sara J., Hughes, David, Hezzell, Melanie J., Butler, Matthew, Neal, Chris, Foster, Rebecca R., Welsh, Gavin I., Finch, Natalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Balliere Tindall 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587354/
https://www.ncbi.nlm.nih.gov/pubmed/35654338
http://dx.doi.org/10.1016/j.tvjl.2022.105843
_version_ 1784813890924707840
author Lawrence-Mills, Sara J.
Hughes, David
Hezzell, Melanie J.
Butler, Matthew
Neal, Chris
Foster, Rebecca R.
Welsh, Gavin I.
Finch, Natalie
author_facet Lawrence-Mills, Sara J.
Hughes, David
Hezzell, Melanie J.
Butler, Matthew
Neal, Chris
Foster, Rebecca R.
Welsh, Gavin I.
Finch, Natalie
author_sort Lawrence-Mills, Sara J.
collection PubMed
description The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx.
format Online
Article
Text
id pubmed-9587354
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Balliere Tindall
record_format MEDLINE/PubMed
spelling pubmed-95873542022-10-24 The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine Lawrence-Mills, Sara J. Hughes, David Hezzell, Melanie J. Butler, Matthew Neal, Chris Foster, Rebecca R. Welsh, Gavin I. Finch, Natalie Vet J Article The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx. Balliere Tindall 2022-07 /pmc/articles/PMC9587354/ /pubmed/35654338 http://dx.doi.org/10.1016/j.tvjl.2022.105843 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lawrence-Mills, Sara J.
Hughes, David
Hezzell, Melanie J.
Butler, Matthew
Neal, Chris
Foster, Rebecca R.
Welsh, Gavin I.
Finch, Natalie
The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine
title The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine
title_full The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine
title_fullStr The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine
title_full_unstemmed The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine
title_short The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine
title_sort microvascular endothelial glycocalyx: an additional piece of the puzzle in veterinary medicine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587354/
https://www.ncbi.nlm.nih.gov/pubmed/35654338
http://dx.doi.org/10.1016/j.tvjl.2022.105843
work_keys_str_mv AT lawrencemillssaraj themicrovascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT hughesdavid themicrovascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT hezzellmelaniej themicrovascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT butlermatthew themicrovascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT nealchris themicrovascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT fosterrebeccar themicrovascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT welshgavini themicrovascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT finchnatalie themicrovascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT lawrencemillssaraj microvascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT hughesdavid microvascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT hezzellmelaniej microvascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT butlermatthew microvascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT nealchris microvascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT fosterrebeccar microvascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT welshgavini microvascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine
AT finchnatalie microvascularendothelialglycocalyxanadditionalpieceofthepuzzleinveterinarymedicine