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1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells

Serine palmitoyltransferase (SPT) predominantly incorporates serine and fatty acyl-CoAs into diverse sphingolipids (SLs) that serve as structural components of membranes and signaling molecules within or amongst cells. However, SPT also uses alanine as a substrate in the contexts of low serine avail...

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Detalles Bibliográficos
Autores principales:	Cordes, Thekla, Kuna, Ramya S., McGregor, Grace H., Khare, Sanika V., Gengatharan, Jivani, Muthusamy, Thangaselvam, Metallo, Christian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587408/ https://www.ncbi.nlm.nih.gov/pubmed/36115594 http://dx.doi.org/10.1016/j.jlr.2022.100281

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