Limited clinical utility for GWAS or polygenic risk score for postoperative acute kidney injury in non-cardiac surgery in European-ancestry patients

BACKGROUND: Prior studies support a genetic basis for postoperative acute kidney injury (AKI). We conducted a genome-wide association study (GWAS), assessed the clinical utility of a polygenic risk score (PRS), and estimated the heritable component of AKI in patients who underwent noncardiac surgery...

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Detalles Bibliográficos
Autores principales: Larach, Daniel B., Lewis, Adam, Bastarache, Lisa, Pandit, Anita, He, Jing, Sinha, Anik, Douville, Nicholas J., Heung, Michael, Mathis, Michael R., Mosley, Jonathan D., Wanderer, Jonathan P., Kheterpal, Sachin, Zawistowski, Matthew, Brummett, Chad M., Siew, Edward D., Robinson-Cohen, Cassianne, Kertai, Miklos D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587619/
https://www.ncbi.nlm.nih.gov/pubmed/36271344
http://dx.doi.org/10.1186/s12882-022-02964-8

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