Cargando…
Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm
BACKGROUND: The clinicopathological characteristics of solid pseudopapillary tumor (SPT) and pancreatic neuroendocrine neoplasm (pNEN) are different. We, therefore, systematically investigated the performance of the clinicopathological characteristics in distinguishing SPT from pNEN. METHODS: We col...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587641/ https://www.ncbi.nlm.nih.gov/pubmed/36271376 http://dx.doi.org/10.1186/s12902-022-01164-7 |
_version_ | 1784813951685492736 |
---|---|
author | Wu, Leshuang Zou, Tianle Shi, Dan Cheng, Huan Shahbaz, Muhammad Umar, Muhammad Li, Tianfeng Zhang, Xianbin Gong, Peng Wei, Yushan |
author_facet | Wu, Leshuang Zou, Tianle Shi, Dan Cheng, Huan Shahbaz, Muhammad Umar, Muhammad Li, Tianfeng Zhang, Xianbin Gong, Peng Wei, Yushan |
author_sort | Wu, Leshuang |
collection | PubMed |
description | BACKGROUND: The clinicopathological characteristics of solid pseudopapillary tumor (SPT) and pancreatic neuroendocrine neoplasm (pNEN) are different. We, therefore, systematically investigated the performance of the clinicopathological characteristics in distinguishing SPT from pNEN. METHODS: We collected the cases from the Surveillance, Epidemiology, and End Results Program. The International Classification of Diseases for Oncology, third edition (ICD-O-3) for tumors was used to identify patients with pNEN or patients with SPT. To determine the performance of age in combination with gender in distinguishing SPT from pNEN, a nomogram was developed and the performance of this nomogram was evaluated by the receiver operating characteristic curve and the area under the curve (AUC). RESULTS: In the training cohort, 563 patients with pNENs and 30 patients with SPTs were recruited. The logistic regression and receiver operating characteristic curves suggest that age, gender, T-stage, N-stage, and M-stage could discriminate SPT and pNEN. The AUC of age, gender, T-stage, N-stage, and M-stage was 0.82, 0.75, 0.65, 0.69, and 0.70, respectively. Based on the nomogram, we observed that the AUC of age and gender is significantly high than that of the T-stage, N-stage, and M-stage. CONCLUSIONS: The present study proposes a non-invasive nomogram that could aid in the differential diagnosis of pNEN and SPT. This might help the clinicians to distinguish SPT from pNEN and choose the appropriate treatments for the patients. |
format | Online Article Text |
id | pubmed-9587641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95876412022-10-23 Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm Wu, Leshuang Zou, Tianle Shi, Dan Cheng, Huan Shahbaz, Muhammad Umar, Muhammad Li, Tianfeng Zhang, Xianbin Gong, Peng Wei, Yushan BMC Endocr Disord Research BACKGROUND: The clinicopathological characteristics of solid pseudopapillary tumor (SPT) and pancreatic neuroendocrine neoplasm (pNEN) are different. We, therefore, systematically investigated the performance of the clinicopathological characteristics in distinguishing SPT from pNEN. METHODS: We collected the cases from the Surveillance, Epidemiology, and End Results Program. The International Classification of Diseases for Oncology, third edition (ICD-O-3) for tumors was used to identify patients with pNEN or patients with SPT. To determine the performance of age in combination with gender in distinguishing SPT from pNEN, a nomogram was developed and the performance of this nomogram was evaluated by the receiver operating characteristic curve and the area under the curve (AUC). RESULTS: In the training cohort, 563 patients with pNENs and 30 patients with SPTs were recruited. The logistic regression and receiver operating characteristic curves suggest that age, gender, T-stage, N-stage, and M-stage could discriminate SPT and pNEN. The AUC of age, gender, T-stage, N-stage, and M-stage was 0.82, 0.75, 0.65, 0.69, and 0.70, respectively. Based on the nomogram, we observed that the AUC of age and gender is significantly high than that of the T-stage, N-stage, and M-stage. CONCLUSIONS: The present study proposes a non-invasive nomogram that could aid in the differential diagnosis of pNEN and SPT. This might help the clinicians to distinguish SPT from pNEN and choose the appropriate treatments for the patients. BioMed Central 2022-10-21 /pmc/articles/PMC9587641/ /pubmed/36271376 http://dx.doi.org/10.1186/s12902-022-01164-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Wu, Leshuang Zou, Tianle Shi, Dan Cheng, Huan Shahbaz, Muhammad Umar, Muhammad Li, Tianfeng Zhang, Xianbin Gong, Peng Wei, Yushan Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm |
title | Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm |
title_full | Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm |
title_fullStr | Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm |
title_full_unstemmed | Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm |
title_short | Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm |
title_sort | age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587641/ https://www.ncbi.nlm.nih.gov/pubmed/36271376 http://dx.doi.org/10.1186/s12902-022-01164-7 |
work_keys_str_mv | AT wuleshuang ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT zoutianle ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT shidan ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT chenghuan ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT shahbazmuhammad ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT umarmuhammad ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT litianfeng ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT zhangxianbin ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT gongpeng ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm AT weiyushan ageincombinationwithgenderisavaluableparameterindifferentialdiagnosisofsolidpseudopapillarytumorsandpancreaticneuroendocrineneoplasm |