Cargando…

Association of Hepatic Steatosis With Coronary Artery Disease by Studying the Role of Individual and Demographic Risk Factors

Background In this study, we aimed to explore the possible association between hepatic steatosis (HS) and coronary artery disease (CAD) by calculating the patients’ calcium scores and comparing clinical and laboratory parameters of patients in King Abdullah Medical City (KAMC), Makkah, Kingdom of Sa...

Descripción completa

Detalles Bibliográficos
Autores principales: Alserihy, Omar, Alsallumi, Yasser, Alzahrani, Fahad, Al-Sulami, Abrar S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587690/
https://www.ncbi.nlm.nih.gov/pubmed/36299925
http://dx.doi.org/10.7759/cureus.29444
_version_ 1784813963605704704
author Alserihy, Omar
Alsallumi, Yasser
Alzahrani, Fahad
Al-Sulami, Abrar S
author_facet Alserihy, Omar
Alsallumi, Yasser
Alzahrani, Fahad
Al-Sulami, Abrar S
author_sort Alserihy, Omar
collection PubMed
description Background In this study, we aimed to explore the possible association between hepatic steatosis (HS) and coronary artery disease (CAD) by calculating the patients’ calcium scores and comparing clinical and laboratory parameters of patients in King Abdullah Medical City (KAMC), Makkah, Kingdom of Saudi Arabia (KSA). The role of risk factors associated with HS was also assessed. Methodology The medical records of 79 patients who underwent coronary cardiac computed tomography (CT) for calcium scoring and enhanced or non-enhanced CT scans of the abdomen and pelvis at the Department of Radiology, KAMC, Makkah, KSA, between April 2012 and April 2013 were collected and analyzed. Results The overall prevalence of HS was 32.9%. Gender, age, and body mass index were significantly associated with HS. Low-dose unenhanced CT is a promising screening test for the determination of HS. A severe grade of calcium score was significantly associated with HS, while hypertension had no significant relation with HS. Biomarkers such as blood urea nitrogen, creatinine, cholesterol, and triglycerides had a significant association with HS, while other liver function tests and lipid profile values did not have a significant association. Bilirubin was significantly higher in non-fatty liver than in fatty liver. Furthermore, higher grades of calcium score were significantly associated with fatty liver in non-hypertensive and non-diabetic patients. Conclusions CAD is closely associated with HS. Moreover, diabetes mellitus and hypertension play a critical role in the development of HS.
format Online
Article
Text
id pubmed-9587690
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-95876902022-10-25 Association of Hepatic Steatosis With Coronary Artery Disease by Studying the Role of Individual and Demographic Risk Factors Alserihy, Omar Alsallumi, Yasser Alzahrani, Fahad Al-Sulami, Abrar S Cureus Cardiology Background In this study, we aimed to explore the possible association between hepatic steatosis (HS) and coronary artery disease (CAD) by calculating the patients’ calcium scores and comparing clinical and laboratory parameters of patients in King Abdullah Medical City (KAMC), Makkah, Kingdom of Saudi Arabia (KSA). The role of risk factors associated with HS was also assessed. Methodology The medical records of 79 patients who underwent coronary cardiac computed tomography (CT) for calcium scoring and enhanced or non-enhanced CT scans of the abdomen and pelvis at the Department of Radiology, KAMC, Makkah, KSA, between April 2012 and April 2013 were collected and analyzed. Results The overall prevalence of HS was 32.9%. Gender, age, and body mass index were significantly associated with HS. Low-dose unenhanced CT is a promising screening test for the determination of HS. A severe grade of calcium score was significantly associated with HS, while hypertension had no significant relation with HS. Biomarkers such as blood urea nitrogen, creatinine, cholesterol, and triglycerides had a significant association with HS, while other liver function tests and lipid profile values did not have a significant association. Bilirubin was significantly higher in non-fatty liver than in fatty liver. Furthermore, higher grades of calcium score were significantly associated with fatty liver in non-hypertensive and non-diabetic patients. Conclusions CAD is closely associated with HS. Moreover, diabetes mellitus and hypertension play a critical role in the development of HS. Cureus 2022-09-22 /pmc/articles/PMC9587690/ /pubmed/36299925 http://dx.doi.org/10.7759/cureus.29444 Text en Copyright © 2022, Alserihy et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Alserihy, Omar
Alsallumi, Yasser
Alzahrani, Fahad
Al-Sulami, Abrar S
Association of Hepatic Steatosis With Coronary Artery Disease by Studying the Role of Individual and Demographic Risk Factors
title Association of Hepatic Steatosis With Coronary Artery Disease by Studying the Role of Individual and Demographic Risk Factors
title_full Association of Hepatic Steatosis With Coronary Artery Disease by Studying the Role of Individual and Demographic Risk Factors
title_fullStr Association of Hepatic Steatosis With Coronary Artery Disease by Studying the Role of Individual and Demographic Risk Factors
title_full_unstemmed Association of Hepatic Steatosis With Coronary Artery Disease by Studying the Role of Individual and Demographic Risk Factors
title_short Association of Hepatic Steatosis With Coronary Artery Disease by Studying the Role of Individual and Demographic Risk Factors
title_sort association of hepatic steatosis with coronary artery disease by studying the role of individual and demographic risk factors
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587690/
https://www.ncbi.nlm.nih.gov/pubmed/36299925
http://dx.doi.org/10.7759/cureus.29444
work_keys_str_mv AT alserihyomar associationofhepaticsteatosiswithcoronaryarterydiseasebystudyingtheroleofindividualanddemographicriskfactors
AT alsallumiyasser associationofhepaticsteatosiswithcoronaryarterydiseasebystudyingtheroleofindividualanddemographicriskfactors
AT alzahranifahad associationofhepaticsteatosiswithcoronaryarterydiseasebystudyingtheroleofindividualanddemographicriskfactors
AT alsulamiabrars associationofhepaticsteatosiswithcoronaryarterydiseasebystudyingtheroleofindividualanddemographicriskfactors