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Sun Exposure Makes no Discrimination based on Vitamin D Status and VDR-Foki Polymorphisms for Non-Melanoma Skin Cancers Risk in Iranian Subjects: A Case-Control Study

BACKGROUND AND OBJECTIVE: Sunlight exposure, the main source of endogenous vitamin D synthesis, may increase the risk of non-melanoma skin cancers (NMSC) development. Vitamin D receptor (VDR) polymorphisms are associated with various malignancies. This study aimed to examine the associations between...

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Autores principales: Rezaiian, Fatemeh, Davoodi, Sayed Hossein, Nikooyeh, Bahareh, Ehsani, Amir Houshang, Kalayi, Ali, Shariatzadeh, Nastaran, Zahedirad, Maliheh, Neyestani, Tirang R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587813/
https://www.ncbi.nlm.nih.gov/pubmed/35763633
http://dx.doi.org/10.31557/APJCP.2022.23.6.1927
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author Rezaiian, Fatemeh
Davoodi, Sayed Hossein
Nikooyeh, Bahareh
Ehsani, Amir Houshang
Kalayi, Ali
Shariatzadeh, Nastaran
Zahedirad, Maliheh
Neyestani, Tirang R
author_facet Rezaiian, Fatemeh
Davoodi, Sayed Hossein
Nikooyeh, Bahareh
Ehsani, Amir Houshang
Kalayi, Ali
Shariatzadeh, Nastaran
Zahedirad, Maliheh
Neyestani, Tirang R
author_sort Rezaiian, Fatemeh
collection PubMed
description BACKGROUND AND OBJECTIVE: Sunlight exposure, the main source of endogenous vitamin D synthesis, may increase the risk of non-melanoma skin cancers (NMSC) development. Vitamin D receptor (VDR) polymorphisms are associated with various malignancies. This study aimed to examine the associations between vitamin D status and VDR FokI polymorphisms in Iranian subjects with NMSC. MATERIALS AND METHODS: This case-control study included 73 diagnosed cases of NMSC and 72 healthy controls from dermatology clinics at Razi Hospital, Tehran, Iran. A questionnaire was used to assess sunlight exposure. The extracted DNA from whole blood samples was genotyped and serum concentrations of 25-hydroxycalciferol (25(OH)D)) and intact parathyroid hormone (iPTH) were measured. RESULTS: We found a significant higher duration of cumulative sunlight exposure in cases compared with controls (p<0.001). However, 25(OH)D and iPTH concentrations were not significantly different between cases and controls (30±15 vs. 29±15 ng/mL, p=0.78 and 46.0±20 vs. 40.5±23 pg/mL, p=0.14, respectively). We did not observe any significant increased risk of NMSC due to f allele, as compared with FF (OR =2.33, 95% CI 0.81-6.75, p=0.12). CONCLUSION: Though sunlight exposure was associated with increased NMSC risk, there were no significant associations between vitamin D status or VDR FokI polymorphisms with NMSC development in our subjects.
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spelling pubmed-95878132022-10-28 Sun Exposure Makes no Discrimination based on Vitamin D Status and VDR-Foki Polymorphisms for Non-Melanoma Skin Cancers Risk in Iranian Subjects: A Case-Control Study Rezaiian, Fatemeh Davoodi, Sayed Hossein Nikooyeh, Bahareh Ehsani, Amir Houshang Kalayi, Ali Shariatzadeh, Nastaran Zahedirad, Maliheh Neyestani, Tirang R Asian Pac J Cancer Prev Research Article BACKGROUND AND OBJECTIVE: Sunlight exposure, the main source of endogenous vitamin D synthesis, may increase the risk of non-melanoma skin cancers (NMSC) development. Vitamin D receptor (VDR) polymorphisms are associated with various malignancies. This study aimed to examine the associations between vitamin D status and VDR FokI polymorphisms in Iranian subjects with NMSC. MATERIALS AND METHODS: This case-control study included 73 diagnosed cases of NMSC and 72 healthy controls from dermatology clinics at Razi Hospital, Tehran, Iran. A questionnaire was used to assess sunlight exposure. The extracted DNA from whole blood samples was genotyped and serum concentrations of 25-hydroxycalciferol (25(OH)D)) and intact parathyroid hormone (iPTH) were measured. RESULTS: We found a significant higher duration of cumulative sunlight exposure in cases compared with controls (p<0.001). However, 25(OH)D and iPTH concentrations were not significantly different between cases and controls (30±15 vs. 29±15 ng/mL, p=0.78 and 46.0±20 vs. 40.5±23 pg/mL, p=0.14, respectively). We did not observe any significant increased risk of NMSC due to f allele, as compared with FF (OR =2.33, 95% CI 0.81-6.75, p=0.12). CONCLUSION: Though sunlight exposure was associated with increased NMSC risk, there were no significant associations between vitamin D status or VDR FokI polymorphisms with NMSC development in our subjects. West Asia Organization for Cancer Prevention 2022-06 /pmc/articles/PMC9587813/ /pubmed/35763633 http://dx.doi.org/10.31557/APJCP.2022.23.6.1927 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. https://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Research Article
Rezaiian, Fatemeh
Davoodi, Sayed Hossein
Nikooyeh, Bahareh
Ehsani, Amir Houshang
Kalayi, Ali
Shariatzadeh, Nastaran
Zahedirad, Maliheh
Neyestani, Tirang R
Sun Exposure Makes no Discrimination based on Vitamin D Status and VDR-Foki Polymorphisms for Non-Melanoma Skin Cancers Risk in Iranian Subjects: A Case-Control Study
title Sun Exposure Makes no Discrimination based on Vitamin D Status and VDR-Foki Polymorphisms for Non-Melanoma Skin Cancers Risk in Iranian Subjects: A Case-Control Study
title_full Sun Exposure Makes no Discrimination based on Vitamin D Status and VDR-Foki Polymorphisms for Non-Melanoma Skin Cancers Risk in Iranian Subjects: A Case-Control Study
title_fullStr Sun Exposure Makes no Discrimination based on Vitamin D Status and VDR-Foki Polymorphisms for Non-Melanoma Skin Cancers Risk in Iranian Subjects: A Case-Control Study
title_full_unstemmed Sun Exposure Makes no Discrimination based on Vitamin D Status and VDR-Foki Polymorphisms for Non-Melanoma Skin Cancers Risk in Iranian Subjects: A Case-Control Study
title_short Sun Exposure Makes no Discrimination based on Vitamin D Status and VDR-Foki Polymorphisms for Non-Melanoma Skin Cancers Risk in Iranian Subjects: A Case-Control Study
title_sort sun exposure makes no discrimination based on vitamin d status and vdr-foki polymorphisms for non-melanoma skin cancers risk in iranian subjects: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587813/
https://www.ncbi.nlm.nih.gov/pubmed/35763633
http://dx.doi.org/10.31557/APJCP.2022.23.6.1927
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