The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily and is mainly expressed on the surface of myeloid cells such as monocytes, macrophages, and neutrophils. It plays an important role in the triggering and amplification of inflammatory responses, a...

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Autores principales: Zhang, Chunyan, Kan, Xugang, Zhang, Baole, Ni, Haibo, Shao, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588203/
https://www.ncbi.nlm.nih.gov/pubmed/36273145
http://dx.doi.org/10.1186/s13041-022-00969-w
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author Zhang, Chunyan
Kan, Xugang
Zhang, Baole
Ni, Haibo
Shao, Jianfeng
author_facet Zhang, Chunyan
Kan, Xugang
Zhang, Baole
Ni, Haibo
Shao, Jianfeng
author_sort Zhang, Chunyan
collection PubMed
description Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily and is mainly expressed on the surface of myeloid cells such as monocytes, macrophages, and neutrophils. It plays an important role in the triggering and amplification of inflammatory responses, and it is involved in the development of various infectious and non-infectious diseases, autoimmune diseases, and cancers. In recent years, TREM-1 has also been found to participate in the pathological processes of several central nervous system (CNS) diseases. Targeting TREM-1 may be a promising strategy for treating these diseases. This paper aims to characterize TREM-1 in terms of its structure, signaling pathway, expression, regulation, ligands and pathophysiological role in CNS diseases.
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spelling pubmed-95882032022-10-24 The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases Zhang, Chunyan Kan, Xugang Zhang, Baole Ni, Haibo Shao, Jianfeng Mol Brain Review Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily and is mainly expressed on the surface of myeloid cells such as monocytes, macrophages, and neutrophils. It plays an important role in the triggering and amplification of inflammatory responses, and it is involved in the development of various infectious and non-infectious diseases, autoimmune diseases, and cancers. In recent years, TREM-1 has also been found to participate in the pathological processes of several central nervous system (CNS) diseases. Targeting TREM-1 may be a promising strategy for treating these diseases. This paper aims to characterize TREM-1 in terms of its structure, signaling pathway, expression, regulation, ligands and pathophysiological role in CNS diseases. BioMed Central 2022-10-22 /pmc/articles/PMC9588203/ /pubmed/36273145 http://dx.doi.org/10.1186/s13041-022-00969-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Chunyan
Kan, Xugang
Zhang, Baole
Ni, Haibo
Shao, Jianfeng
The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
title The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
title_full The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
title_fullStr The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
title_full_unstemmed The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
title_short The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
title_sort role of triggering receptor expressed on myeloid cells-1 (trem-1) in central nervous system diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588203/
https://www.ncbi.nlm.nih.gov/pubmed/36273145
http://dx.doi.org/10.1186/s13041-022-00969-w
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