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SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways

BACKGROUND: Oxidative stress-caused damage to the retinal pigment epithelium (RPE) underlies the onset and progression of age-related macular degeneration (AMD). Impaired mitochondrial biogenesis sensitizes RPE cells to mitochondrial dysfunction, energy insufficiency and death. Src-homology 2 domain...

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Detalles Bibliográficos
Autores principales:	Zhuang, Xiaonan, Ma, Jun, Xu, Gezhi, Sun, Zhongcui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588232/ https://www.ncbi.nlm.nih.gov/pubmed/36273174 http://dx.doi.org/10.1186/s10020-022-00554-w

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