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Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

BACKGROUND: Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great potential as tumor avatars for drug response prediction in PDAC, yet they disregard...

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Detalles Bibliográficos
Autores principales:	Schuth, Sebastian, Le Blanc, Solange, Krieger, Teresa G., Jabs, Julia, Schenk, Miriam, Giese, Nathalia A., Büchler, Markus W., Eils, Roland, Conrad, Christian, Strobel, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588250/ https://www.ncbi.nlm.nih.gov/pubmed/36273171 http://dx.doi.org/10.1186/s13046-022-02519-7

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