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Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment

Cancer has been one of the most dominant causes of mortality globally over the last few decades. In cancer treatment, the selective targeting of tumor cells is indispensable, making it a better replacement for conventional chemotherapies by diminishing their adverse side effects. While designing a d...

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Autores principales: Rasel, Md. Shamiul Islam, Mohona, Farhana Afrin, Akter, Wahida, Kabir, Shaila, Chowdhury, Abu Asad, Chowdhury, Jakir Ahmed, Hassan, Md. Abul, Al Mamun, Abdullah, Ghose, Dipayon Krisna, Ahmad, Zubair, Khan, Farhat S., Bari, Md. Fazlul, Rahman, Md. Sohanur, Amran, Md. Shah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588330/
https://www.ncbi.nlm.nih.gov/pubmed/36284633
http://dx.doi.org/10.1155/2022/9396760
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author Rasel, Md. Shamiul Islam
Mohona, Farhana Afrin
Akter, Wahida
Kabir, Shaila
Chowdhury, Abu Asad
Chowdhury, Jakir Ahmed
Hassan, Md. Abul
Al Mamun, Abdullah
Ghose, Dipayon Krisna
Ahmad, Zubair
Khan, Farhat S.
Bari, Md. Fazlul
Rahman, Md. Sohanur
Amran, Md. Shah
author_facet Rasel, Md. Shamiul Islam
Mohona, Farhana Afrin
Akter, Wahida
Kabir, Shaila
Chowdhury, Abu Asad
Chowdhury, Jakir Ahmed
Hassan, Md. Abul
Al Mamun, Abdullah
Ghose, Dipayon Krisna
Ahmad, Zubair
Khan, Farhat S.
Bari, Md. Fazlul
Rahman, Md. Sohanur
Amran, Md. Shah
author_sort Rasel, Md. Shamiul Islam
collection PubMed
description Cancer has been one of the most dominant causes of mortality globally over the last few decades. In cancer treatment, the selective targeting of tumor cells is indispensable, making it a better replacement for conventional chemotherapies by diminishing their adverse side effects. While designing a drug to be delivered selectively in the target organ, the drug development scientists should focus on various factors such as the type of cancer they are dealing with according to which drug, targeting moieties, and pharmaceutical carriers should be targeted. All published articles have been collected regarding cancer and drug-targeting approaches from well reputed databases including MEDLINE, Embase, Cochrane Library, CENTRAL and ClinicalTrials.gov, Science Direct, PubMed, Scopus, Wiley, and Springer. The articles published between January 2010 and December 2020 were considered. Due to the existence of various mechanisms, it is challenging to choose which one is appropriate for a specific case. Moreover, a combination of more than one approach is often utilized to achieve optimal drug effects. In this review, we have summarized and highlighted central mechanisms of how the targeted drug delivery system works in the specific diseased microenvironment, along with the strategies to make an approach more effective. We have also included some pictorial illustrations to have a precise idea about different types of drug targeting. The core contribution of this work includes providing a cancer drug development scientist with a broad preliminary idea to choose the appropriate approach among the various targeted drug delivery mechanisms. Also, the study will contribute to improving anticancer treatment approaches by providing a pathway for lesser side effects observed in conventional chemotherapeutic techniques.
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spelling pubmed-95883302022-10-24 Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment Rasel, Md. Shamiul Islam Mohona, Farhana Afrin Akter, Wahida Kabir, Shaila Chowdhury, Abu Asad Chowdhury, Jakir Ahmed Hassan, Md. Abul Al Mamun, Abdullah Ghose, Dipayon Krisna Ahmad, Zubair Khan, Farhat S. Bari, Md. Fazlul Rahman, Md. Sohanur Amran, Md. Shah J Oncol Review Article Cancer has been one of the most dominant causes of mortality globally over the last few decades. In cancer treatment, the selective targeting of tumor cells is indispensable, making it a better replacement for conventional chemotherapies by diminishing their adverse side effects. While designing a drug to be delivered selectively in the target organ, the drug development scientists should focus on various factors such as the type of cancer they are dealing with according to which drug, targeting moieties, and pharmaceutical carriers should be targeted. All published articles have been collected regarding cancer and drug-targeting approaches from well reputed databases including MEDLINE, Embase, Cochrane Library, CENTRAL and ClinicalTrials.gov, Science Direct, PubMed, Scopus, Wiley, and Springer. The articles published between January 2010 and December 2020 were considered. Due to the existence of various mechanisms, it is challenging to choose which one is appropriate for a specific case. Moreover, a combination of more than one approach is often utilized to achieve optimal drug effects. In this review, we have summarized and highlighted central mechanisms of how the targeted drug delivery system works in the specific diseased microenvironment, along with the strategies to make an approach more effective. We have also included some pictorial illustrations to have a precise idea about different types of drug targeting. The core contribution of this work includes providing a cancer drug development scientist with a broad preliminary idea to choose the appropriate approach among the various targeted drug delivery mechanisms. Also, the study will contribute to improving anticancer treatment approaches by providing a pathway for lesser side effects observed in conventional chemotherapeutic techniques. Hindawi 2022-09-29 /pmc/articles/PMC9588330/ /pubmed/36284633 http://dx.doi.org/10.1155/2022/9396760 Text en Copyright © 2022 Md. Shamiul Islam Rasel et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rasel, Md. Shamiul Islam
Mohona, Farhana Afrin
Akter, Wahida
Kabir, Shaila
Chowdhury, Abu Asad
Chowdhury, Jakir Ahmed
Hassan, Md. Abul
Al Mamun, Abdullah
Ghose, Dipayon Krisna
Ahmad, Zubair
Khan, Farhat S.
Bari, Md. Fazlul
Rahman, Md. Sohanur
Amran, Md. Shah
Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment
title Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment
title_full Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment
title_fullStr Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment
title_full_unstemmed Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment
title_short Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment
title_sort exploration of site-specific drug targeting—a review on epr-, stimuli-, chemical-, and receptor-based approaches as potential drug targeting methods in cancer treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588330/
https://www.ncbi.nlm.nih.gov/pubmed/36284633
http://dx.doi.org/10.1155/2022/9396760
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