Cargando…

Exploring Anti-Type 2 Diabetes Mellitus Mechanism of Gegen Qinlian Decoction by Network Pharmacology and Experimental Validation

PURPOSE: Gegen Qinlian Decoction (GGQL) has been employed to treat type 2 diabetes mellitus (T2DM) in the clinical practice of traditional Chinese medicine. However, the underlying mechanism of GGQL in the treatment of T2DM remains unknown. This study was aimed at exploring the pharmacological mecha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bao, Weiping, Sun, Hongping, Wu, Xiang, Xu, Juan, Zhang, Huifeng, Cao, Lin, Fan, Yaofu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588339/ https://www.ncbi.nlm.nih.gov/pubmed/36284987 http://dx.doi.org/10.1155/2022/1927688

Ejemplares similares

Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction
por: Lu, Jing-Ze, et al.
Publicado: (2021)

Network Pharmacology–Based Analysis and Experimental Exploration of Antidiabetic Mechanisms of Gegen Qinlian Decoction
por: Xu, Yu, et al.
Publicado: (2021)

Based on Network Pharmacology to Explore the Molecular Targets and Mechanisms of Gegen Qinlian Decoction for the Treatment of Ulcerative Colitis
por: Wei, Meiqi, et al.
Publicado: (2020)

Network Pharmacology-Based Study on the Mechanism of Gegen Qinlian Decoction against Colorectal Cancer
por: Fan, Qiaowei, et al.
Publicado: (2020)

The potential effects and mechanisms of Gegen Qinlian Decoction in oxaliplatin-resistant colorectal cancer based on network pharmacology
por: Lin, Xiang, et al.
Publicado: (2022)

Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice
por: Han, Jing, et al.
Publicado: (2017)

Exploration of the Mechanism of the Control of Coccidiosis in Chickens Based on Network Pharmacology and Molecular Docking With the Addition of Modified Gegen Qinlian Decoction
por: Peng, Xiaomin, et al.
Publicado: (2022)

Integrated Pharmacology Reveals the Molecular Mechanism of Gegen Qinlian Decoction Against Lipopolysaccharide-induced Acute Lung Injury
por: Li, Wei, et al.
Publicado: (2022)

Gegen Qinlian Decoction treatment of asymptomatic hyperuricemia by targeting circadian immune function
por: Wang, Xiaojun, et al.
Publicado: (2023)

Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Gegen Qinlian Decoction for Rotavirus Enteritis
por: Zhong, Peicheng, et al.
Publicado: (2020)

Scientific Evidence of Chinese Herbal Medicine (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis
por: Huang, Jinke, et al.
Publicado: (2022)

Molecular mechanism of the effect of Gegen Qinlian decoction on COVID-19 comorbid with diabetes mellitus based on network pharmacology and molecular docking: A review
por: Li, Lin-zi, et al.
Publicado: (2023)

Herbal Formula Gegen-Qinlian Decoction for Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials
por: Ren, Lin, et al.
Publicado: (2020)

Gegen Qinlian Decoction combined with Metformin for the treatment of patients with Type-2 Diabetes Mellitus: A retrospective observational study
por: Chen, Yingqi, et al.
Publicado: (2023)

Gegen Qinlian Decoction Attenuates High-Fat Diet-Induced Steatohepatitis in Rats via Gut Microbiota
por: Guo, Yi, et al.
Publicado: (2018)

Gegen Qinlian Decoction Relieves Ulcerative Colitis via Adjusting Dysregulated Nrf2/ARE Signaling
por: Lin, Chuan, et al.
Publicado: (2022)

Efficacy and Safety of Gegen Qinlian Decoction for Pediatric Diarrhea: A Systematic Review and Meta-Analysis
por: Wang, Dan, et al.
Publicado: (2022)

Gegen Qinlian Decoction Ameliorates Hepatic Insulin Resistance by Silent Information Regulator1 (SIRT1)-Dependent Deacetylation of Forkhead Box O1 (FOXO1)
por: Sui, Miao, et al.
Publicado: (2019)

Gegen Qinlian Decoction Treats Diarrhea in Piglets by Modulating Gut Microbiota and Short-Chain Fatty Acids
por: Liu, Chang-Shun, et al.
Publicado: (2019)

Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine
por: Xu, Xizhan, et al.
Publicado: (2020)

In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis
por: Liu, Xiaolu, et al.
Publicado: (2021)

Tissue distribution and integrated pharmacokinetic properties of major effective constituents of oral Gegen-Qinlian decoction in mice
por: Lu, Jing-Ze, et al.
Publicado: (2022)

Metformin and Gegen Qinlian Decoction boost islet α-cell proliferation of the STZ induced diabetic rats
por: Xu, Li, et al.
Publicado: (2022)

Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids
por: Wang, Xue, et al.
Publicado: (2023)

Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination
por: Chen, Jiamei, et al.
Publicado: (2023)

Efficacy of herbal medicine (Gegen Qinlian Decoction) on ulcerative colitis: A systematic review of randomized controlled trials
por: Fan, Yuling, et al.
Publicado: (2019)

Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway
por: Wang, Xiao-Jun, et al.
Publicado: (2021)

Focal Microscopy Observe the Mechanism of Gegen Qinlian Decoction Treating Type 2 Diabetic Nephropathy in Nude Mice
por: Zheng, Fei, et al.
Publicado: (2022)

Administration of modified Gegen Qinlian decoction for hemorrhagic chronic radiation proctitis: A case report and review of literature
por: Liu, Shao-Yong, et al.
Publicado: (2023)

Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon
por: Lu, Xue, et al.
Publicado: (2023)

Gegen Qinlian Decoction Alleviates Experimental Colitis and Concurrent Lung Inflammation by Inhibiting the Recruitment of Inflammatory Myeloid Cells and Restoring Microbial Balance
por: Li, Yalan, et al.
Publicado: (2022)

The effect of Gegen Qinlian Decoction on clinical prognosis and islet function for type 2 diabetic mellitus: A protocol for systematic review and meta-analysis
por: Ren, Yuhang, et al.
Publicado: (2021)

Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota
por: Li, Yang, et al.
Publicado: (2020)

Retracted: Focal Microscopy Observe the Mechanism of Gegen Qinlian Decoction Treating Type 2 Diabetic Nephropathy in Nude Mice
por: International, BioMed Research
Publicado: (2023)

A 42-Markers Pharmacokinetic Study Reveals Interactions of Berberine and Glycyrrhizic Acid in the Anti-diabetic Chinese Medicine Formula Gegen-Qinlian Decoction
por: Qiao, Xue, et al.
Publicado: (2018)

Compound to Extract to Formulation: a knowledge-transmitting approach for metabolites identification of Gegen-Qinlian Decoction, a traditional Chinese medicine formula
por: Qiao, Xue, et al.
Publicado: (2016)

Modified Gegen Qinlian Decoction Regulates Treg/Th17 Balance to Ameliorate DSS-Induced Acute Experimental Colitis in Mice by Altering the Gut Microbiota
por: Wang, Yifan, et al.
Publicado: (2021)

Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment
por: Lv, Ji, et al.
Publicado: (2019)

Gegen Qinlian Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats via Oxidative Stress, Inflammation, and the NLRP3 Signal Axis
por: Ying, Yuqi, et al.
Publicado: (2021)

Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol
por: Guo, Yi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g198k050lmslv74ts9b875n9rv