Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion

Chemotherapy elicits tumor immune evasion with poorly characterized mechanisms. Here, we demonstrate that chemotherapy markedly enhances the expression levels of CD47 in osteosarcoma tissues, which are positively associated with patient mortality. We reveal that macrophages in response to chemothera...

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Detalles Bibliográficos
Autores principales: Wang, Zenan, Li, Binghao, Li, Shan, Lin, Wenlong, Wang, Zhan, Wang, Shengdong, Chen, Weida, Shi, Wei, Chen, Tao, Zhou, Hao, Yinwang, Eloy, Zhang, Wenkan, Mou, Haochen, Chai, Xupeng, Zhang, Jiahao, Lu, Zhimin, Ye, Zhaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588779/
https://www.ncbi.nlm.nih.gov/pubmed/36274066
http://dx.doi.org/10.1038/s41467-022-34064-4

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