Methylation subgroup and molecular heterogeneity is a hallmark of glioblastoma: implications for biopsy targeting, classification and therapy

BACKGROUND: Intratumoral heterogeneity at the cellular and molecular level is a hallmark of glioblastoma (GB) that contributes to treatment resistance and poor clinical outcome. Little is known regarding epigenetic heterogeneity and intratumoral phylogeny and their implication for molecular classifi...

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Detalles Bibliográficos
Autores principales: Gempt, J., Withake, F., Aftahy, A.K., Meyer, H.S., Barz, M., Delbridge, C., Liesche-Starnecker, F., Prokop, G., Pfarr, N., Schlegel, J., Meyer, B., Zimmer, C., Menze, B.H., Wiestler, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588899/
https://www.ncbi.nlm.nih.gov/pubmed/36055049
http://dx.doi.org/10.1016/j.esmoop.2022.100566

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