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Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is the basic pathological process of many degenerative diseases of the spine, characterized by series of symptoms, among which low back pain (LBP) is the most common symptom that patients suffer a lot, which not only makes patients and individual families bear...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588944/ https://www.ncbi.nlm.nih.gov/pubmed/36299288 http://dx.doi.org/10.3389/fbioe.2022.1023877 |
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author | Wei, Bingqian Zhao, Yingjing Li, Weihang Zhang, Shilei Yan, Ming Hu, Zebing Gao, Bo |
author_facet | Wei, Bingqian Zhao, Yingjing Li, Weihang Zhang, Shilei Yan, Ming Hu, Zebing Gao, Bo |
author_sort | Wei, Bingqian |
collection | PubMed |
description | Intervertebral disc degeneration (IDD) is the basic pathological process of many degenerative diseases of the spine, characterized by series of symptoms, among which low back pain (LBP) is the most common symptom that patients suffer a lot, which not only makes patients and individual families bear a huge pain and psychological burden, but also consumes a lot of medical resources. IDD is usually thought to be relevant with various factors such as genetic predisposition, trauma and aging, and IDD progression is tightly relevant with structural and functional alterations. IDD processes are caused by series of pathological processes, including oxidative stress, matrix decomposition, inflammatory reaction, apoptosis, abnormal proliferation, cell senescence, autophagy as well as sepsis process, among which the oxidative stress and inflammatory response are considered as key link in IDD. The production and clearance of ROS are tightly connected with oxidative stress, which would further simulate various signaling pathways. The phenotype of disc cells could change from matrix anabolism-to matrix catabolism- and proinflammatory-phenotype during IDD. Recent decades, with the relevant reports about oxidative stress and inflammatory response in IDD increasing gradually, the mechanisms researches have attracted much more attention. Consequently, this study focused on the indispensable roles of the oxidative stress and inflammatory response (especially macrophages and cytokines) to illustrate the origin, development, and deterioration of IDD, aiming to provide novel insights in the molecular mechanisms as well as significant clinical values for IDD. |
format | Online Article Text |
id | pubmed-9588944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95889442022-10-25 Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration Wei, Bingqian Zhao, Yingjing Li, Weihang Zhang, Shilei Yan, Ming Hu, Zebing Gao, Bo Front Bioeng Biotechnol Bioengineering and Biotechnology Intervertebral disc degeneration (IDD) is the basic pathological process of many degenerative diseases of the spine, characterized by series of symptoms, among which low back pain (LBP) is the most common symptom that patients suffer a lot, which not only makes patients and individual families bear a huge pain and psychological burden, but also consumes a lot of medical resources. IDD is usually thought to be relevant with various factors such as genetic predisposition, trauma and aging, and IDD progression is tightly relevant with structural and functional alterations. IDD processes are caused by series of pathological processes, including oxidative stress, matrix decomposition, inflammatory reaction, apoptosis, abnormal proliferation, cell senescence, autophagy as well as sepsis process, among which the oxidative stress and inflammatory response are considered as key link in IDD. The production and clearance of ROS are tightly connected with oxidative stress, which would further simulate various signaling pathways. The phenotype of disc cells could change from matrix anabolism-to matrix catabolism- and proinflammatory-phenotype during IDD. Recent decades, with the relevant reports about oxidative stress and inflammatory response in IDD increasing gradually, the mechanisms researches have attracted much more attention. Consequently, this study focused on the indispensable roles of the oxidative stress and inflammatory response (especially macrophages and cytokines) to illustrate the origin, development, and deterioration of IDD, aiming to provide novel insights in the molecular mechanisms as well as significant clinical values for IDD. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9588944/ /pubmed/36299288 http://dx.doi.org/10.3389/fbioe.2022.1023877 Text en Copyright © 2022 Wei, Zhao, Li, Zhang, Yan, Hu and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Wei, Bingqian Zhao, Yingjing Li, Weihang Zhang, Shilei Yan, Ming Hu, Zebing Gao, Bo Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration |
title | Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration |
title_full | Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration |
title_fullStr | Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration |
title_full_unstemmed | Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration |
title_short | Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration |
title_sort | innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588944/ https://www.ncbi.nlm.nih.gov/pubmed/36299288 http://dx.doi.org/10.3389/fbioe.2022.1023877 |
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