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Enhancing microalgal lipid accumulation for biofuel production
Microalgae have high lipid accumulation capacity, high growth rate and high photosynthetic efficiency which are considered as one of the most promising alternative sustainable feedstocks for producing lipid-based biofuels. However, commercialization feasibility of microalgal biofuel production is st...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588965/ https://www.ncbi.nlm.nih.gov/pubmed/36299727 http://dx.doi.org/10.3389/fmicb.2022.1024441 |
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author | Zhu, Zhi Sun, Jing Fa, Yun Liu, Xufeng Lindblad, Peter |
author_facet | Zhu, Zhi Sun, Jing Fa, Yun Liu, Xufeng Lindblad, Peter |
author_sort | Zhu, Zhi |
collection | PubMed |
description | Microalgae have high lipid accumulation capacity, high growth rate and high photosynthetic efficiency which are considered as one of the most promising alternative sustainable feedstocks for producing lipid-based biofuels. However, commercialization feasibility of microalgal biofuel production is still conditioned to the high production cost. Enhancement of lipid accumulation in microalgae play a significant role in boosting the economics of biofuel production based on microalgal lipid. The major challenge of enhancing microalgal lipid accumulation lies in overcoming the trade-off between microalgal cell growth and lipid accumulation. Substantial approaches including genetic modifications of microalgal strains by metabolic engineering and process regulations of microalgae cultivation by integrating multiple optimization strategies widely applied in industrial microbiology have been investigated. In the present review, we critically discuss recent trends in the application of multiple molecular strategies to construct high performance microalgal strains by metabolic engineering and synergistic strategies of process optimization and stress operation to enhance microalgal lipid accumulation for biofuel production. Additionally, this review aims to emphasize the opportunities and challenges regarding scaled application of the strategic integration and its viability to make microalgal biofuel production a commercial reality in the near future. |
format | Online Article Text |
id | pubmed-9588965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95889652022-10-25 Enhancing microalgal lipid accumulation for biofuel production Zhu, Zhi Sun, Jing Fa, Yun Liu, Xufeng Lindblad, Peter Front Microbiol Microbiology Microalgae have high lipid accumulation capacity, high growth rate and high photosynthetic efficiency which are considered as one of the most promising alternative sustainable feedstocks for producing lipid-based biofuels. However, commercialization feasibility of microalgal biofuel production is still conditioned to the high production cost. Enhancement of lipid accumulation in microalgae play a significant role in boosting the economics of biofuel production based on microalgal lipid. The major challenge of enhancing microalgal lipid accumulation lies in overcoming the trade-off between microalgal cell growth and lipid accumulation. Substantial approaches including genetic modifications of microalgal strains by metabolic engineering and process regulations of microalgae cultivation by integrating multiple optimization strategies widely applied in industrial microbiology have been investigated. In the present review, we critically discuss recent trends in the application of multiple molecular strategies to construct high performance microalgal strains by metabolic engineering and synergistic strategies of process optimization and stress operation to enhance microalgal lipid accumulation for biofuel production. Additionally, this review aims to emphasize the opportunities and challenges regarding scaled application of the strategic integration and its viability to make microalgal biofuel production a commercial reality in the near future. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9588965/ /pubmed/36299727 http://dx.doi.org/10.3389/fmicb.2022.1024441 Text en Copyright © 2022 Zhu, Sun, Fa, Liu and Lindblad. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Zhu, Zhi Sun, Jing Fa, Yun Liu, Xufeng Lindblad, Peter Enhancing microalgal lipid accumulation for biofuel production |
title | Enhancing microalgal lipid accumulation for biofuel production |
title_full | Enhancing microalgal lipid accumulation for biofuel production |
title_fullStr | Enhancing microalgal lipid accumulation for biofuel production |
title_full_unstemmed | Enhancing microalgal lipid accumulation for biofuel production |
title_short | Enhancing microalgal lipid accumulation for biofuel production |
title_sort | enhancing microalgal lipid accumulation for biofuel production |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588965/ https://www.ncbi.nlm.nih.gov/pubmed/36299727 http://dx.doi.org/10.3389/fmicb.2022.1024441 |
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