Cargando…
Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages
OBJECTIVE: The purpose of this study was to examine bone turnover markers, estradiol, parathyroid hormone, and 25 hydroxyvitamin D, in cynomolgus monkeys at different ages to improve our understanding of the changes in bone turnover markers throughout the life cycle of cynomolgus monkeys and to prov...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588968/ https://www.ncbi.nlm.nih.gov/pubmed/36299457 http://dx.doi.org/10.3389/fendo.2022.984523 |
_version_ | 1784814192721657856 |
---|---|
author | Li, Ying Cai, Qijun Dong, Chenchen Hou, Lu Li, Yingxin Guo, Bin Zeng, Chunyuan Cheng, Yong Shang, Jingjie Ling, Xueying Gong, Jian Xu, Hao |
author_facet | Li, Ying Cai, Qijun Dong, Chenchen Hou, Lu Li, Yingxin Guo, Bin Zeng, Chunyuan Cheng, Yong Shang, Jingjie Ling, Xueying Gong, Jian Xu, Hao |
author_sort | Li, Ying |
collection | PubMed |
description | OBJECTIVE: The purpose of this study was to examine bone turnover markers, estradiol, parathyroid hormone, and 25 hydroxyvitamin D, in cynomolgus monkeys at different ages to improve our understanding of the changes in bone turnover markers throughout the life cycle of cynomolgus monkeys and to provide a basis for the establishment of a non-human primate model of osteoporosis. METHODS: Total Body Bone Mineral Density and Total Body Bone Mineral Content were measured using Dual-Energy X-Ray Absorptiometry in cynomolgus monkeys at different ages. Serum bone turnover marker' levels were measured using enzyme immunoassays at each age group, and the relationship between bone turnover markers and age was assessed by Spearman rank correlation analysis to investigate the relationship between bone turnover markers and age in female cynomolgus monkeys. RESULTS: Total Body Bone Mineral Density in female cynomolgus monkeys peaked at 10 years of age and then formed a plateau that was maintained until old age. Procollagen I Aminoterminal Propeptide, Bone Alkaline Phosphatase, Osteocalcin, and C-Terminal Telopeptide Of Type I Collagen peaked at 1 to 3 years of age and gradually decreased with age, leveling off by 10 years of age. Estradiol, parathyroid hormone, and 25 hydroxyvitamin D, follicle-stimulating hormone, luteinizing hormone, were not significantly different among age groups. CONCLUSION: This paper provides data on trends in bone turnover markers throughout the life cycle of female cynomolgus monkeys, which are similar to human changes. |
format | Online Article Text |
id | pubmed-9588968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95889682022-10-25 Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages Li, Ying Cai, Qijun Dong, Chenchen Hou, Lu Li, Yingxin Guo, Bin Zeng, Chunyuan Cheng, Yong Shang, Jingjie Ling, Xueying Gong, Jian Xu, Hao Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: The purpose of this study was to examine bone turnover markers, estradiol, parathyroid hormone, and 25 hydroxyvitamin D, in cynomolgus monkeys at different ages to improve our understanding of the changes in bone turnover markers throughout the life cycle of cynomolgus monkeys and to provide a basis for the establishment of a non-human primate model of osteoporosis. METHODS: Total Body Bone Mineral Density and Total Body Bone Mineral Content were measured using Dual-Energy X-Ray Absorptiometry in cynomolgus monkeys at different ages. Serum bone turnover marker' levels were measured using enzyme immunoassays at each age group, and the relationship between bone turnover markers and age was assessed by Spearman rank correlation analysis to investigate the relationship between bone turnover markers and age in female cynomolgus monkeys. RESULTS: Total Body Bone Mineral Density in female cynomolgus monkeys peaked at 10 years of age and then formed a plateau that was maintained until old age. Procollagen I Aminoterminal Propeptide, Bone Alkaline Phosphatase, Osteocalcin, and C-Terminal Telopeptide Of Type I Collagen peaked at 1 to 3 years of age and gradually decreased with age, leveling off by 10 years of age. Estradiol, parathyroid hormone, and 25 hydroxyvitamin D, follicle-stimulating hormone, luteinizing hormone, were not significantly different among age groups. CONCLUSION: This paper provides data on trends in bone turnover markers throughout the life cycle of female cynomolgus monkeys, which are similar to human changes. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9588968/ /pubmed/36299457 http://dx.doi.org/10.3389/fendo.2022.984523 Text en Copyright © 2022 Li, Cai, Dong, Hou, Li, Guo, Zeng, Cheng, Shang, Ling, Gong and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Li, Ying Cai, Qijun Dong, Chenchen Hou, Lu Li, Yingxin Guo, Bin Zeng, Chunyuan Cheng, Yong Shang, Jingjie Ling, Xueying Gong, Jian Xu, Hao Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
title | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
title_full | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
title_fullStr | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
title_full_unstemmed | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
title_short | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
title_sort | analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588968/ https://www.ncbi.nlm.nih.gov/pubmed/36299457 http://dx.doi.org/10.3389/fendo.2022.984523 |
work_keys_str_mv | AT liying analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT caiqijun analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT dongchenchen analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT houlu analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT liyingxin analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT guobin analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT zengchunyuan analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT chengyong analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT shangjingjie analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT lingxueying analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT gongjian analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages AT xuhao analysisofserumboneturnovermarkersinfemalecynomolgusmonkeysofdifferentages |