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Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease

BACKGROUND: Cerebral small vessel disease (CSVD) is associated with the pathogenesis of Alzheimer’s disease (AD). Effective treatments to alleviate AD are still not currently available. Hence, we explored markers and underlying molecular mechanisms associated with AD by utilizing gene expression pro...

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Autores principales: Zou, Chun, Huang, Xiaohua, Zhang, Yilong, Pan, Mika, Xie, Jieqiong, Chen, Liechun, Meng, Youshi, Zou, Donghua, Luo, Jiefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588985/
https://www.ncbi.nlm.nih.gov/pubmed/36299860
http://dx.doi.org/10.3389/fnmol.2022.996107
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author Zou, Chun
Huang, Xiaohua
Zhang, Yilong
Pan, Mika
Xie, Jieqiong
Chen, Liechun
Meng, Youshi
Zou, Donghua
Luo, Jiefeng
author_facet Zou, Chun
Huang, Xiaohua
Zhang, Yilong
Pan, Mika
Xie, Jieqiong
Chen, Liechun
Meng, Youshi
Zou, Donghua
Luo, Jiefeng
author_sort Zou, Chun
collection PubMed
description BACKGROUND: Cerebral small vessel disease (CSVD) is associated with the pathogenesis of Alzheimer’s disease (AD). Effective treatments to alleviate AD are still not currently available. Hence, we explored markers and underlying molecular mechanisms associated with AD by utilizing gene expression profiles of AD and CSVD patients from public databases, providing more options for early diagnosis and its treatment. METHODS: Gene expression profiles were collected from GSE63060 (for AD) and GSE162790 (for CSVD). Differential analysis was performed between AD and mild cognitive impairment (MCI) or CSVD progression and CSVD no-progression. In both datasets, differentially expressed genes (DEGs) with the same expression direction were identified as common DEGs. Then protein-protein interaction (PPI) network was constructed for common DEGs. Differential immune cells and checkpoints were calculated between AD and MCI. RESULTS: A total of 146 common DEGs were identified. Common DEGs were mainly enriched in endocytosis and oxytocin signaling pathways. Interestingly, endocytosis and metabolic pathways were shown both from MCI to AD and from CSVD no-progression to CSVD progression. Moreover, SIRT1 was identified as a key gene by ranking degree of connectivity in the PPI network. SIRT1 was associated with obesity-related genes and metabolic disorders. Additionally, SIRT1 showed correlations with CD8 T cells, NK CD56 bright cells, and checkpoints in AD. CONCLUSION: The study revealed that the progression of AD is associated with abnormalities in gene expression and metabolism and that the SIRT1 gene may serve as a promising therapeutic target for the treatment of AD.
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spelling pubmed-95889852022-10-25 Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease Zou, Chun Huang, Xiaohua Zhang, Yilong Pan, Mika Xie, Jieqiong Chen, Liechun Meng, Youshi Zou, Donghua Luo, Jiefeng Front Mol Neurosci Neuroscience BACKGROUND: Cerebral small vessel disease (CSVD) is associated with the pathogenesis of Alzheimer’s disease (AD). Effective treatments to alleviate AD are still not currently available. Hence, we explored markers and underlying molecular mechanisms associated with AD by utilizing gene expression profiles of AD and CSVD patients from public databases, providing more options for early diagnosis and its treatment. METHODS: Gene expression profiles were collected from GSE63060 (for AD) and GSE162790 (for CSVD). Differential analysis was performed between AD and mild cognitive impairment (MCI) or CSVD progression and CSVD no-progression. In both datasets, differentially expressed genes (DEGs) with the same expression direction were identified as common DEGs. Then protein-protein interaction (PPI) network was constructed for common DEGs. Differential immune cells and checkpoints were calculated between AD and MCI. RESULTS: A total of 146 common DEGs were identified. Common DEGs were mainly enriched in endocytosis and oxytocin signaling pathways. Interestingly, endocytosis and metabolic pathways were shown both from MCI to AD and from CSVD no-progression to CSVD progression. Moreover, SIRT1 was identified as a key gene by ranking degree of connectivity in the PPI network. SIRT1 was associated with obesity-related genes and metabolic disorders. Additionally, SIRT1 showed correlations with CD8 T cells, NK CD56 bright cells, and checkpoints in AD. CONCLUSION: The study revealed that the progression of AD is associated with abnormalities in gene expression and metabolism and that the SIRT1 gene may serve as a promising therapeutic target for the treatment of AD. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9588985/ /pubmed/36299860 http://dx.doi.org/10.3389/fnmol.2022.996107 Text en Copyright © 2022 Zou, Huang, Zhang, Pan, Xie, Chen, Meng, Zou and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zou, Chun
Huang, Xiaohua
Zhang, Yilong
Pan, Mika
Xie, Jieqiong
Chen, Liechun
Meng, Youshi
Zou, Donghua
Luo, Jiefeng
Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease
title Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease
title_full Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease
title_fullStr Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease
title_full_unstemmed Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease
title_short Potential biomarkers of Alzheimer’s disease and cerebral small vessel disease
title_sort potential biomarkers of alzheimer’s disease and cerebral small vessel disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588985/
https://www.ncbi.nlm.nih.gov/pubmed/36299860
http://dx.doi.org/10.3389/fnmol.2022.996107
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