Natural killer cell infusion for cytomegalovirus infection in pediatric patients with Wiskott-Aldrich syndrome following cord blood transplantation: A case report and literature review

NK cells have important functions in resisting cytomegalovirus infection, as they proliferate after viral infection and have certain immunological memory. Here, we report infusion of haploid donor-derived natural killer cells to treat two pediatric patients with Wiskott-Aldrich syndrome (WAS) who we...

Descripción completa

Detalles Bibliográficos
Autores principales: Yue, Yongwei, Meng, Lijun, Ling, Jing, Fan, Liyan, Zhang, Yanlei, Hu, Yixin, Chang, Alex H., Hu, Shaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588986/
https://www.ncbi.nlm.nih.gov/pubmed/36300184
http://dx.doi.org/10.3389/fmed.2022.988847
_version_ 1784814197653110784
author Yue, Yongwei
Meng, Lijun
Ling, Jing
Fan, Liyan
Zhang, Yanlei
Hu, Yixin
Chang, Alex H.
Hu, Shaoyan
author_facet Yue, Yongwei
Meng, Lijun
Ling, Jing
Fan, Liyan
Zhang, Yanlei
Hu, Yixin
Chang, Alex H.
Hu, Shaoyan
author_sort Yue, Yongwei
collection PubMed
description NK cells have important functions in resisting cytomegalovirus infection, as they proliferate after viral infection and have certain immunological memory. Here, we report infusion of haploid donor-derived natural killer cells to treat two pediatric patients with Wiskott-Aldrich syndrome (WAS) who were infected with cytomegalovirus after cord blood transplantation (CBT), which successfully cleared the viral infection in both patients.
format Online
Article
Text
id pubmed-9588986
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95889862022-10-25 Natural killer cell infusion for cytomegalovirus infection in pediatric patients with Wiskott-Aldrich syndrome following cord blood transplantation: A case report and literature review Yue, Yongwei Meng, Lijun Ling, Jing Fan, Liyan Zhang, Yanlei Hu, Yixin Chang, Alex H. Hu, Shaoyan Front Med (Lausanne) Medicine NK cells have important functions in resisting cytomegalovirus infection, as they proliferate after viral infection and have certain immunological memory. Here, we report infusion of haploid donor-derived natural killer cells to treat two pediatric patients with Wiskott-Aldrich syndrome (WAS) who were infected with cytomegalovirus after cord blood transplantation (CBT), which successfully cleared the viral infection in both patients. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9588986/ /pubmed/36300184 http://dx.doi.org/10.3389/fmed.2022.988847 Text en Copyright © 2022 Yue, Meng, Ling, Fan, Zhang, Hu, Chang and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Yue, Yongwei
Meng, Lijun
Ling, Jing
Fan, Liyan
Zhang, Yanlei
Hu, Yixin
Chang, Alex H.
Hu, Shaoyan
Natural killer cell infusion for cytomegalovirus infection in pediatric patients with Wiskott-Aldrich syndrome following cord blood transplantation: A case report and literature review
title Natural killer cell infusion for cytomegalovirus infection in pediatric patients with Wiskott-Aldrich syndrome following cord blood transplantation: A case report and literature review
title_full Natural killer cell infusion for cytomegalovirus infection in pediatric patients with Wiskott-Aldrich syndrome following cord blood transplantation: A case report and literature review
title_fullStr Natural killer cell infusion for cytomegalovirus infection in pediatric patients with Wiskott-Aldrich syndrome following cord blood transplantation: A case report and literature review
title_full_unstemmed Natural killer cell infusion for cytomegalovirus infection in pediatric patients with Wiskott-Aldrich syndrome following cord blood transplantation: A case report and literature review
title_short Natural killer cell infusion for cytomegalovirus infection in pediatric patients with Wiskott-Aldrich syndrome following cord blood transplantation: A case report and literature review
title_sort natural killer cell infusion for cytomegalovirus infection in pediatric patients with wiskott-aldrich syndrome following cord blood transplantation: a case report and literature review
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588986/
https://www.ncbi.nlm.nih.gov/pubmed/36300184
http://dx.doi.org/10.3389/fmed.2022.988847
work_keys_str_mv AT yueyongwei naturalkillercellinfusionforcytomegalovirusinfectioninpediatricpatientswithwiskottaldrichsyndromefollowingcordbloodtransplantationacasereportandliteraturereview
AT menglijun naturalkillercellinfusionforcytomegalovirusinfectioninpediatricpatientswithwiskottaldrichsyndromefollowingcordbloodtransplantationacasereportandliteraturereview
AT lingjing naturalkillercellinfusionforcytomegalovirusinfectioninpediatricpatientswithwiskottaldrichsyndromefollowingcordbloodtransplantationacasereportandliteraturereview
AT fanliyan naturalkillercellinfusionforcytomegalovirusinfectioninpediatricpatientswithwiskottaldrichsyndromefollowingcordbloodtransplantationacasereportandliteraturereview
AT zhangyanlei naturalkillercellinfusionforcytomegalovirusinfectioninpediatricpatientswithwiskottaldrichsyndromefollowingcordbloodtransplantationacasereportandliteraturereview
AT huyixin naturalkillercellinfusionforcytomegalovirusinfectioninpediatricpatientswithwiskottaldrichsyndromefollowingcordbloodtransplantationacasereportandliteraturereview
AT changalexh naturalkillercellinfusionforcytomegalovirusinfectioninpediatricpatientswithwiskottaldrichsyndromefollowingcordbloodtransplantationacasereportandliteraturereview
AT hushaoyan naturalkillercellinfusionforcytomegalovirusinfectioninpediatricpatientswithwiskottaldrichsyndromefollowingcordbloodtransplantationacasereportandliteraturereview

Ejemplares similares