Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b

The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a conserved Wnt2 and Wnt9b expression in endothelial cells (ECs) in zone 3. EC-elimination of Wnt2 and Wnt9b led to...

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Detalles Bibliográficos
Autores principales: Hu, Shikai, Liu, Silvia, Bian, Yu, Poddar, Minakshi, Singh, Sucha, Cao, Catherine, McGaughey, Jackson, Bell, Aaron, Blazer, Levi L., Adams, Jarret J., Sidhu, Sachdev S., Angers, Stephane, Monga, Satdarshan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9588996/
https://www.ncbi.nlm.nih.gov/pubmed/36220068
http://dx.doi.org/10.1016/j.xcrm.2022.100754

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