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Mucosal-homing natural killer cells are associated with aging in persons living with HIV
Natural killer (NK) cells are critical modulators of HIV transmission and disease. Recent evidence suggests a loss of NK cell cytotoxicity during aging, yet analysis of NK cell biology and aging in people with HIV (PWH) is lacking. Herein, we perform comprehensive analyses of people aging with and w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589002/ https://www.ncbi.nlm.nih.gov/pubmed/36208628 http://dx.doi.org/10.1016/j.xcrm.2022.100773 |
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author | Kroll, Kyle W. Shah, Spandan V. Lucar, Olivier A. Premeaux, Thomas A. Shikuma, Cecilia M. Corley, Michael J. Mosher, Matthew Woolley, Griffin Bowler, Scott Ndhlovu, Lishomwa C. Reeves, R. Keith |
author_facet | Kroll, Kyle W. Shah, Spandan V. Lucar, Olivier A. Premeaux, Thomas A. Shikuma, Cecilia M. Corley, Michael J. Mosher, Matthew Woolley, Griffin Bowler, Scott Ndhlovu, Lishomwa C. Reeves, R. Keith |
author_sort | Kroll, Kyle W. |
collection | PubMed |
description | Natural killer (NK) cells are critical modulators of HIV transmission and disease. Recent evidence suggests a loss of NK cell cytotoxicity during aging, yet analysis of NK cell biology and aging in people with HIV (PWH) is lacking. Herein, we perform comprehensive analyses of people aging with and without HIV to determine age-related NK phenotypic changes. Utilizing high-dimensional flow cytometry, we analyze 30 immune-related proteins on peripheral NK cells from healthy donors, PWH with viral suppression, and viremic PWH. NK cell phenotypes are dynamic across aging but change significantly in HIV and on antiretroviral drug therapy (ART). NK cells in healthy aging show increasing ⍺4β7 and decreasing CCR7 expression and a reverse phenomenon in PWH. These HIV-associated trafficking patterns could be due to NK cell recruitment to HIV reservoir formation in lymphoid tissue or failed mucosal signaling in the HIV-infected gut but appear to be tight delineators of age-related NK cell changes. |
format | Online Article Text |
id | pubmed-9589002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-95890022022-10-25 Mucosal-homing natural killer cells are associated with aging in persons living with HIV Kroll, Kyle W. Shah, Spandan V. Lucar, Olivier A. Premeaux, Thomas A. Shikuma, Cecilia M. Corley, Michael J. Mosher, Matthew Woolley, Griffin Bowler, Scott Ndhlovu, Lishomwa C. Reeves, R. Keith Cell Rep Med Article Natural killer (NK) cells are critical modulators of HIV transmission and disease. Recent evidence suggests a loss of NK cell cytotoxicity during aging, yet analysis of NK cell biology and aging in people with HIV (PWH) is lacking. Herein, we perform comprehensive analyses of people aging with and without HIV to determine age-related NK phenotypic changes. Utilizing high-dimensional flow cytometry, we analyze 30 immune-related proteins on peripheral NK cells from healthy donors, PWH with viral suppression, and viremic PWH. NK cell phenotypes are dynamic across aging but change significantly in HIV and on antiretroviral drug therapy (ART). NK cells in healthy aging show increasing ⍺4β7 and decreasing CCR7 expression and a reverse phenomenon in PWH. These HIV-associated trafficking patterns could be due to NK cell recruitment to HIV reservoir formation in lymphoid tissue or failed mucosal signaling in the HIV-infected gut but appear to be tight delineators of age-related NK cell changes. Elsevier 2022-10-07 /pmc/articles/PMC9589002/ /pubmed/36208628 http://dx.doi.org/10.1016/j.xcrm.2022.100773 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Kroll, Kyle W. Shah, Spandan V. Lucar, Olivier A. Premeaux, Thomas A. Shikuma, Cecilia M. Corley, Michael J. Mosher, Matthew Woolley, Griffin Bowler, Scott Ndhlovu, Lishomwa C. Reeves, R. Keith Mucosal-homing natural killer cells are associated with aging in persons living with HIV |
title | Mucosal-homing natural killer cells are associated with aging in persons living with HIV |
title_full | Mucosal-homing natural killer cells are associated with aging in persons living with HIV |
title_fullStr | Mucosal-homing natural killer cells are associated with aging in persons living with HIV |
title_full_unstemmed | Mucosal-homing natural killer cells are associated with aging in persons living with HIV |
title_short | Mucosal-homing natural killer cells are associated with aging in persons living with HIV |
title_sort | mucosal-homing natural killer cells are associated with aging in persons living with hiv |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589002/ https://www.ncbi.nlm.nih.gov/pubmed/36208628 http://dx.doi.org/10.1016/j.xcrm.2022.100773 |
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