Memory CD4(+) T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency

Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) suppress CD4(+) T cell activation and may promote latent HIV infection. By performing leukapheresis (n = 21) and lymph node biopsies (n = 8) in people with HIV on antiretroviral therapy (ART) and sorting memory CD4...

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Detalles Bibliográficos
Autores principales: Rasmussen, Thomas A., Zerbato, Jennifer M., Rhodes, Ajantha, Tumpach, Carolin, Dantanarayana, Ashanti, McMahon, James H., Lau, Jillian S.Y., Chang, J. Judy, Gubser, Celine, Brown, Wendy, Hoh, Rebecca, Krone, Melissa, Pascoe, Rachel, Chiu, Chris Y., Bramhall, Michael, Lee, Hyun Jae, Haque, Ashraful, Fromentin, Rèmi, Chomont, Nicolas, Milush, Jeffrey, Van der Sluis, Renee M., Palmer, Sarah, Deeks, Steven G., Cameron, Paul U., Evans, Vanessa, Lewin, Sharon R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589005/
https://www.ncbi.nlm.nih.gov/pubmed/36198308
http://dx.doi.org/10.1016/j.xcrm.2022.100766

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