Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping

ZnO quantum dots (QDs) have received much attention as biomarkers and drug delivery systems in cancer treatment, due to their low cost, ease of preparation, and pH-responsive degradation. However, its applications are limited by the low quantum yield and light absorption. In this work, a lanthanum-d...

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Autores principales: Hao, Ruixin, Luo, Shanshan, Wang, Feiyan, Pan, Xinyu, Yao, Jing, Wu, Jielian, Fang, Haihong, Li, Wenkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589047/
https://www.ncbi.nlm.nih.gov/pubmed/36300028
http://dx.doi.org/10.3389/fchem.2022.1042038
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author Hao, Ruixin
Luo, Shanshan
Wang, Feiyan
Pan, Xinyu
Yao, Jing
Wu, Jielian
Fang, Haihong
Li, Wenkui
author_facet Hao, Ruixin
Luo, Shanshan
Wang, Feiyan
Pan, Xinyu
Yao, Jing
Wu, Jielian
Fang, Haihong
Li, Wenkui
author_sort Hao, Ruixin
collection PubMed
description ZnO quantum dots (QDs) have received much attention as biomarkers and drug delivery systems in cancer treatment, due to their low cost, ease of preparation, and pH-responsive degradation. However, its applications are limited by the low quantum yield and light absorption. In this work, a lanthanum-doped zinc oxide (La-ZnO) QDs-based drug delivery platform was constructed. The results show that 4% La doping is the most beneficial for improving the fluorescent properties of the ZnO QDs. After loading the drug, the cell activity was 15% at ZnO@DOX and 12% at La-ZnO@DOX. According to in vitro and in vivo experiment results, the La-ZnO QDs show enhancement of the antitumor effect. Dual enhancement of fluorescence and anti-tumor effects make La-ZnO QDs promising as a drug delivery system in cancer treatment.
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spelling pubmed-95890472022-10-25 Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping Hao, Ruixin Luo, Shanshan Wang, Feiyan Pan, Xinyu Yao, Jing Wu, Jielian Fang, Haihong Li, Wenkui Front Chem Chemistry ZnO quantum dots (QDs) have received much attention as biomarkers and drug delivery systems in cancer treatment, due to their low cost, ease of preparation, and pH-responsive degradation. However, its applications are limited by the low quantum yield and light absorption. In this work, a lanthanum-doped zinc oxide (La-ZnO) QDs-based drug delivery platform was constructed. The results show that 4% La doping is the most beneficial for improving the fluorescent properties of the ZnO QDs. After loading the drug, the cell activity was 15% at ZnO@DOX and 12% at La-ZnO@DOX. According to in vitro and in vivo experiment results, the La-ZnO QDs show enhancement of the antitumor effect. Dual enhancement of fluorescence and anti-tumor effects make La-ZnO QDs promising as a drug delivery system in cancer treatment. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9589047/ /pubmed/36300028 http://dx.doi.org/10.3389/fchem.2022.1042038 Text en Copyright © 2022 Hao, Luo, Wang, Pan, Yao, Wu, Fang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Hao, Ruixin
Luo, Shanshan
Wang, Feiyan
Pan, Xinyu
Yao, Jing
Wu, Jielian
Fang, Haihong
Li, Wenkui
Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping
title Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping
title_full Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping
title_fullStr Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping
title_full_unstemmed Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping
title_short Enhancement of fluorescence and anti-tumor effect of ZnO QDs by La doping
title_sort enhancement of fluorescence and anti-tumor effect of zno qds by la doping
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589047/
https://www.ncbi.nlm.nih.gov/pubmed/36300028
http://dx.doi.org/10.3389/fchem.2022.1042038
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