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Biological effects of COVID-19 on lung cancer: Can we drive our decisions

COVID-19 infection caused by SARS-CoV-2 is considered catastrophic because it affects multiple organs, particularly those of the respiratory tract. Although the consequences of this infection are not fully clear, it causes damage to the lungs, the cardiovascular and nervous systems, and other organs...

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Autores principales: Aramini, Beatrice, Masciale, Valentina, Samarelli, Anna Valeria, Tonelli, Roberto, Cerri, Stefania, Clini, Enrico, Stella, Franco, Dominici, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589049/
https://www.ncbi.nlm.nih.gov/pubmed/36300087
http://dx.doi.org/10.3389/fonc.2022.1029830
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author Aramini, Beatrice
Masciale, Valentina
Samarelli, Anna Valeria
Tonelli, Roberto
Cerri, Stefania
Clini, Enrico
Stella, Franco
Dominici, Massimo
author_facet Aramini, Beatrice
Masciale, Valentina
Samarelli, Anna Valeria
Tonelli, Roberto
Cerri, Stefania
Clini, Enrico
Stella, Franco
Dominici, Massimo
author_sort Aramini, Beatrice
collection PubMed
description COVID-19 infection caused by SARS-CoV-2 is considered catastrophic because it affects multiple organs, particularly those of the respiratory tract. Although the consequences of this infection are not fully clear, it causes damage to the lungs, the cardiovascular and nervous systems, and other organs, subsequently inducing organ failure. In particular, the effects of SARS-CoV-2-induced inflammation on cancer cells and the tumor microenvironment need to be investigated. COVID-19 may alter the tumor microenvironment, promoting cancer cell proliferation and dormant cancer cell (DCC) reawakening. DCCs reawakened upon infection with SARS-CoV-2 can populate the premetastatic niche in the lungs and other organs, leading to tumor dissemination. DCC reawakening and consequent neutrophil and monocyte/macrophage activation with an uncontrolled cascade of pro-inflammatory cytokines are the most severe clinical effects of COVID-19. Moreover, neutrophil extracellular traps have been demonstrated to activate the dissemination of premetastatic cells into the lungs. Further studies are warranted to better define the roles of COVID-19 in inflammation as well as in tumor development and tumor cell metastasis; the results of these studies will aid in the development of further targeted therapies, both for cancer prevention and the treatment of patients with COVID-19.
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spelling pubmed-95890492022-10-25 Biological effects of COVID-19 on lung cancer: Can we drive our decisions Aramini, Beatrice Masciale, Valentina Samarelli, Anna Valeria Tonelli, Roberto Cerri, Stefania Clini, Enrico Stella, Franco Dominici, Massimo Front Oncol Oncology COVID-19 infection caused by SARS-CoV-2 is considered catastrophic because it affects multiple organs, particularly those of the respiratory tract. Although the consequences of this infection are not fully clear, it causes damage to the lungs, the cardiovascular and nervous systems, and other organs, subsequently inducing organ failure. In particular, the effects of SARS-CoV-2-induced inflammation on cancer cells and the tumor microenvironment need to be investigated. COVID-19 may alter the tumor microenvironment, promoting cancer cell proliferation and dormant cancer cell (DCC) reawakening. DCCs reawakened upon infection with SARS-CoV-2 can populate the premetastatic niche in the lungs and other organs, leading to tumor dissemination. DCC reawakening and consequent neutrophil and monocyte/macrophage activation with an uncontrolled cascade of pro-inflammatory cytokines are the most severe clinical effects of COVID-19. Moreover, neutrophil extracellular traps have been demonstrated to activate the dissemination of premetastatic cells into the lungs. Further studies are warranted to better define the roles of COVID-19 in inflammation as well as in tumor development and tumor cell metastasis; the results of these studies will aid in the development of further targeted therapies, both for cancer prevention and the treatment of patients with COVID-19. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9589049/ /pubmed/36300087 http://dx.doi.org/10.3389/fonc.2022.1029830 Text en Copyright © 2022 Aramini, Masciale, Samarelli, Tonelli, Cerri, Clini, Stella and Dominici https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Aramini, Beatrice
Masciale, Valentina
Samarelli, Anna Valeria
Tonelli, Roberto
Cerri, Stefania
Clini, Enrico
Stella, Franco
Dominici, Massimo
Biological effects of COVID-19 on lung cancer: Can we drive our decisions
title Biological effects of COVID-19 on lung cancer: Can we drive our decisions
title_full Biological effects of COVID-19 on lung cancer: Can we drive our decisions
title_fullStr Biological effects of COVID-19 on lung cancer: Can we drive our decisions
title_full_unstemmed Biological effects of COVID-19 on lung cancer: Can we drive our decisions
title_short Biological effects of COVID-19 on lung cancer: Can we drive our decisions
title_sort biological effects of covid-19 on lung cancer: can we drive our decisions
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589049/
https://www.ncbi.nlm.nih.gov/pubmed/36300087
http://dx.doi.org/10.3389/fonc.2022.1029830
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