Peroxynitrite promotes immune evasion by reducing tumor antigenicity

A study by Tcyganov et al.(1) demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficac...

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Detalles Bibliográficos
Autores principales: Capietto, Aude-Hélène, Delamarre, Lélia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589093/
https://www.ncbi.nlm.nih.gov/pubmed/36260983
http://dx.doi.org/10.1016/j.xcrm.2022.100787
Descripción
Sumario:A study by Tcyganov et al.(1) demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficacy preclinically.

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