Peroxynitrite promotes immune evasion by reducing tumor antigenicity

A study by Tcyganov et al.(1) demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficac...

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Detalles Bibliográficos
Autores principales: Capietto, Aude-Hélène, Delamarre, Lélia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589093/
https://www.ncbi.nlm.nih.gov/pubmed/36260983
http://dx.doi.org/10.1016/j.xcrm.2022.100787
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author Capietto, Aude-Hélène
Delamarre, Lélia
author_facet Capietto, Aude-Hélène
Delamarre, Lélia
author_sort Capietto, Aude-Hélène
collection PubMed
description A study by Tcyganov et al.(1) demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficacy preclinically.
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spelling pubmed-95890932022-10-25 Peroxynitrite promotes immune evasion by reducing tumor antigenicity Capietto, Aude-Hélène Delamarre, Lélia Cell Rep Med Spotlight A study by Tcyganov et al.(1) demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficacy preclinically. Elsevier 2022-10-18 /pmc/articles/PMC9589093/ /pubmed/36260983 http://dx.doi.org/10.1016/j.xcrm.2022.100787 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Spotlight
Capietto, Aude-Hélène
Delamarre, Lélia
Peroxynitrite promotes immune evasion by reducing tumor antigenicity
title Peroxynitrite promotes immune evasion by reducing tumor antigenicity
title_full Peroxynitrite promotes immune evasion by reducing tumor antigenicity
title_fullStr Peroxynitrite promotes immune evasion by reducing tumor antigenicity
title_full_unstemmed Peroxynitrite promotes immune evasion by reducing tumor antigenicity
title_short Peroxynitrite promotes immune evasion by reducing tumor antigenicity
title_sort peroxynitrite promotes immune evasion by reducing tumor antigenicity
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589093/
https://www.ncbi.nlm.nih.gov/pubmed/36260983
http://dx.doi.org/10.1016/j.xcrm.2022.100787
work_keys_str_mv AT capiettoaudehelene peroxynitritepromotesimmuneevasionbyreducingtumorantigenicity
AT delamarrelelia peroxynitritepromotesimmuneevasionbyreducingtumorantigenicity

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