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Peroxynitrite promotes immune evasion by reducing tumor antigenicity
A study by Tcyganov et al.(1) demonstrates that peroxynitrite, an oxidant abundant in the tumor microenvironment, changes the repertoire of MHC class I peptides presented by tumors and limits immune recognition. Peroxynitrite inhibition in combination with immune checkpoint blockade enhances efficac...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589093/ https://www.ncbi.nlm.nih.gov/pubmed/36260983 http://dx.doi.org/10.1016/j.xcrm.2022.100787 |