Cargando…

Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review

We initially described two children who developed Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML), and reviewed five adult patients from the literature. Through analysis of the clinical features, laboratory examination, treatment and prognostic data from these seven patients, we fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Xin-Ying, Han, Tong-Li, Lv, Jun-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589109/
https://www.ncbi.nlm.nih.gov/pubmed/36299686
http://dx.doi.org/10.3389/fped.2022.1001775
_version_ 1784814227631898624
author Yang, Xin-Ying
Han, Tong-Li
Lv, Jun-Lan
author_facet Yang, Xin-Ying
Han, Tong-Li
Lv, Jun-Lan
author_sort Yang, Xin-Ying
collection PubMed
description We initially described two children who developed Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML), and reviewed five adult patients from the literature. Through analysis of the clinical features, laboratory examination, treatment and prognostic data from these seven patients, we found that when GBS “meets” RML, the most prominent characteristics were the following: male dominance; limb weakness, pain and respiratory failure could be caused by multiple factors; limb weakness and respiratory muscle paralysis were more serious than with GBS alone; and the probability of mechanical ventilation was increased. Neuroelectrophysiological studies revealed axonal lesions. Close monitoring and timely identification and intervention to remedy potentially fatal complications such as electrolyte disorder multisystem complications and kidney injury are crucial. With plasma exchange, peritoneal dialysis and supportive treatment, the long-term outcome of most patients was satisfactory.
format Online
Article
Text
id pubmed-9589109
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95891092022-10-25 Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review Yang, Xin-Ying Han, Tong-Li Lv, Jun-Lan Front Pediatr Pediatrics We initially described two children who developed Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML), and reviewed five adult patients from the literature. Through analysis of the clinical features, laboratory examination, treatment and prognostic data from these seven patients, we found that when GBS “meets” RML, the most prominent characteristics were the following: male dominance; limb weakness, pain and respiratory failure could be caused by multiple factors; limb weakness and respiratory muscle paralysis were more serious than with GBS alone; and the probability of mechanical ventilation was increased. Neuroelectrophysiological studies revealed axonal lesions. Close monitoring and timely identification and intervention to remedy potentially fatal complications such as electrolyte disorder multisystem complications and kidney injury are crucial. With plasma exchange, peritoneal dialysis and supportive treatment, the long-term outcome of most patients was satisfactory. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9589109/ /pubmed/36299686 http://dx.doi.org/10.3389/fped.2022.1001775 Text en Copyright © 2022 Yang, Han and Lv. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Yang, Xin-Ying
Han, Tong-Li
Lv, Jun-Lan
Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review
title Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review
title_full Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review
title_fullStr Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review
title_full_unstemmed Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review
title_short Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review
title_sort guillain-barré syndrome (gbs) complicated by rhabdomyolysis (rml): case reports of 2 children and literature review
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589109/
https://www.ncbi.nlm.nih.gov/pubmed/36299686
http://dx.doi.org/10.3389/fped.2022.1001775
work_keys_str_mv AT yangxinying guillainbarresyndromegbscomplicatedbyrhabdomyolysisrmlcasereportsof2childrenandliteraturereview
AT hantongli guillainbarresyndromegbscomplicatedbyrhabdomyolysisrmlcasereportsof2childrenandliteraturereview
AT lvjunlan guillainbarresyndromegbscomplicatedbyrhabdomyolysisrmlcasereportsof2childrenandliteraturereview