Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

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Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins, including additional neuraminidase (NA). This eva...

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Detalles Bibliográficos
Autores principales: Chang, Cheng, Music, Nedzad, Cheung, Michael, Rossignol, Evan, Bedi, Sukhmani, Patel, Harsh, Safari, Mohammad, Lee, Changkeun, Otten, Gillis R., Settembre, Ethan C., Palladino, Giuseppe, Wen, Yingxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589142/
https://www.ncbi.nlm.nih.gov/pubmed/36320414
http://dx.doi.org/10.1016/j.omtm.2022.09.013
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