Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy

Congenital generalized lipodystrophy type 2 is a serious multisystem disorder with limited treatment options. It is caused by mutations affecting the BSCL2 gene, which encodes the protein seipin. Patients with congenital generalized lipodystrophy type 2 lack both metabolic and mechanical adipose tis...

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Detalles Bibliográficos
Autores principales: Sommer, Nadine, Roumane, Ahlima, Han, Weiping, Delibegović, Mirela, Rochford, Justin J., Mcilroy, George D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589143/
https://www.ncbi.nlm.nih.gov/pubmed/36320417
http://dx.doi.org/10.1016/j.omtm.2022.09.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589143/
https://www.ncbi.nlm.nih.gov/pubmed/36320417
http://dx.doi.org/10.1016/j.omtm.2022.09.014

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