Cargando…

Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy

Congenital generalized lipodystrophy type 2 is a serious multisystem disorder with limited treatment options. It is caused by mutations affecting the BSCL2 gene, which encodes the protein seipin. Patients with congenital generalized lipodystrophy type 2 lack both metabolic and mechanical adipose tis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sommer, Nadine, Roumane, Ahlima, Han, Weiping, Delibegović, Mirela, Rochford, Justin J., Mcilroy, George D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589143/ https://www.ncbi.nlm.nih.gov/pubmed/36320417 http://dx.doi.org/10.1016/j.omtm.2022.09.014

Ejemplares similares

Bscl2 Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy
por: Roumane, Ahlima, et al.
Publicado: (2021)

Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy
por: Mcilroy, George D., et al.
Publicado: (2020)

Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation
por: Sim, M. F. Michelle, et al.
Publicado: (2020)

Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet
por: Mcilroy, George D., et al.
Publicado: (2018)

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease
por: Mcilroy, George D., et al.
Publicado: (2018)

Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells
por: Roumane, Ahlima, et al.
Publicado: (2018)

Evaluation of epicardial adipose tissue in familial partial lipodystrophy
por: Godoy-Matos, Amélio Fernando, et al.
Publicado: (2015)

Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
por: Verschoor, Pola J., et al.
Publicado: (2021)

Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation
por: Qiang, Guifen, et al.
Publicado: (2016)

Neuroanatomical Characterisation of the Expression of the Lipodystrophy and Motor-Neuropathy Gene Bscl2 in Adult Mouse Brain
por: Garfield, Alastair S., et al.
Publicado: (2012)

Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
por: Domingo, Pere, et al.
Publicado: (2022)

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue
por: Mcilroy, George D., et al.
Publicado: (2016)

Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus
por: Mcilroy, George D., et al.
Publicado: (2013)

Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model
por: Munoz, Marcos, et al.
Publicado: (2023)

Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model
por: Munoz, Marcos David, et al.
Publicado: (2023)

Lipodystrophies—Disorders of the Fatty Tissue
por: Knebel, Birgit, et al.
Publicado: (2020)

Lipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD
por: Softic, Samir, et al.
Publicado: (2016)

Genetic and cytometric analyses of subcutaneous adipose tissue in patients with hemophilia and HIV-associated lipodystrophy
por: Mashiko, Takanobu, et al.
Publicado: (2022)

Endoplasmic reticulum stress activation in adipose tissue induces metabolic syndrome in individuals with familial partial lipodystrophy of the Dunnigan type
por: Foss-Freitas, Maria C., et al.
Publicado: (2018)

Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes
por: Hoggard, Nigel, et al.
Publicado: (2012)

HIV/AIDS and lipodystrophy: Implications for clinical management in resource-limited settings
por: Finkelstein, Julia L, et al.
Publicado: (2015)

Comparison of Dorsocervical With Abdominal Subcutaneous Adipose Tissue in Patients With and Without Antiretroviral Therapy–Associated Lipodystrophy
por: Sevastianova, Ksenia, et al.
Publicado: (2011)

Berardinelli–Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing
por: Zhou, Hongyi, et al.
Publicado: (2020)

Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles
por: Treiber, Guillaume, et al.
Publicado: (2023)

Not Enough Fat: Mouse Models of Inherited Lipodystrophy
por: Le Lay, Soazig, et al.
Publicado: (2022)

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
por: Payne, Victoria A., et al.
Publicado: (2008)

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms
por: Sim, M. F. Michelle, et al.
Publicado: (2013)

Quantitative and qualitative differences in subcutaneous adipose tissue stores across lipodystrophy types shown by magnetic resonance imaging
por: Al-Attar, Salam A, et al.
Publicado: (2007)

Towards a mechanistic understanding of lipodystrophy and seipin functions
por: Wee, Kenneth, et al.
Publicado: (2014)

Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
por: Mantzoros, Christos S.
Publicado: (2012)

Deletion of myeloid-PTP1B decreases MHC Class I expression and peptide presentation through an IL-10 dependent mechanism in response to LPS challenge
por: Le Sommer, Samantha, et al.
Publicado: (2015)

The acromegaly lipodystrophy
por: Freda, Pamela U.
Publicado: (2022)

Inhibition of Angiopoietin-Like 3 (ANGPTL3) Reduces Adipose Tissue Insulin Resistance in Patients With Familial Partial Lipodystrophy
por: de Freitas, Maria Cristina Foss, et al.
Publicado: (2021)

Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity
por: McGrath, Cody, et al.
Publicado: (2022)

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21
por: Lees, Emma K, et al.
Publicado: (2014)

Abnormal Adipose Tissue Distribution with Unfavorable Metabolic Profile in Five Children Following Hematopoietic Stem Cell Transplantation: A New Etiology for Acquired Partial Lipodystrophy
por: Adachi, Masanori, et al.
Publicado: (2013)

Delayed Presentation of Berardinelli-Siep Lipodystrophy in an Adolescent Female
por: Cleary, Courtney, et al.
Publicado: (2023)

A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion
por: Mann, Jake P, et al.
Publicado: (2023)

Lipodystrophy and metabolic syndrome in Romanian HIV-infected adults
por: Arbune, M
Publicado: (2010)

Visceral fat does not contribute to metabolic disease in lipodystrophy
por: Malandrino, N., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_uegtq07r8j0pc46vss2r04f9b9