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Rate-limiting hydrolysis in ribosomal release reactions revealed by ester activation

Translation terminates by releasing the polypeptide chain in one of two chemical reactions catalyzed by the ribosome. Release is also a target for engineering, as readthrough of a stop codon enables incorporation of unnatural amino acids and treatment of genetic diseases. Hydrolysis of the ester bon...

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Detalles Bibliográficos
Autores principales: Bao, Letian, Karpenko, Victoriia V., Forster, Anthony C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589212/
https://www.ncbi.nlm.nih.gov/pubmed/36300356
http://dx.doi.org/10.1016/j.jbc.2022.102509

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