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Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes
Stent thrombosis remains one of the main causes that lead to vascular stent failure in patients undergoing percutaneous coronary intervention (PCI). Type 2 diabetes mellitus is accompanied by endothelial dysfunction and platelet hyperactivity and is associated with suboptimal outcomes following PCI,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589287/ https://www.ncbi.nlm.nih.gov/pubmed/36299902 http://dx.doi.org/10.3389/fphar.2022.982185 |
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author | Marei, Isra Ahmetaj-Shala, Blerina Triggle, Chris R. |
author_facet | Marei, Isra Ahmetaj-Shala, Blerina Triggle, Chris R. |
author_sort | Marei, Isra |
collection | PubMed |
description | Stent thrombosis remains one of the main causes that lead to vascular stent failure in patients undergoing percutaneous coronary intervention (PCI). Type 2 diabetes mellitus is accompanied by endothelial dysfunction and platelet hyperactivity and is associated with suboptimal outcomes following PCI, and an increase in the incidence of late stent thrombosis. Evidence suggests that late stent thrombosis is caused by the delayed and impaired endothelialization of the lumen of the stent. The endothelium has a key role in modulating inflammation and thrombosis and maintaining homeostasis, thus restoring a functional endothelial cell layer is an important target for the prevention of stent thrombosis. Modifications using specific molecules to induce endothelial cell adhesion, proliferation and function can improve stents endothelialization and prevent thrombosis. Blood endothelial progenitor cells (EPCs) represent a potential cell source for the in situ-endothelialization of vascular conduits and stents. We aim in this review to summarize the main biofunctionalization strategies to induce the in-situ endothelialization of coronary artery stents using circulating endothelial stem cells. |
format | Online Article Text |
id | pubmed-9589287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95892872022-10-25 Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes Marei, Isra Ahmetaj-Shala, Blerina Triggle, Chris R. Front Pharmacol Pharmacology Stent thrombosis remains one of the main causes that lead to vascular stent failure in patients undergoing percutaneous coronary intervention (PCI). Type 2 diabetes mellitus is accompanied by endothelial dysfunction and platelet hyperactivity and is associated with suboptimal outcomes following PCI, and an increase in the incidence of late stent thrombosis. Evidence suggests that late stent thrombosis is caused by the delayed and impaired endothelialization of the lumen of the stent. The endothelium has a key role in modulating inflammation and thrombosis and maintaining homeostasis, thus restoring a functional endothelial cell layer is an important target for the prevention of stent thrombosis. Modifications using specific molecules to induce endothelial cell adhesion, proliferation and function can improve stents endothelialization and prevent thrombosis. Blood endothelial progenitor cells (EPCs) represent a potential cell source for the in situ-endothelialization of vascular conduits and stents. We aim in this review to summarize the main biofunctionalization strategies to induce the in-situ endothelialization of coronary artery stents using circulating endothelial stem cells. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9589287/ /pubmed/36299902 http://dx.doi.org/10.3389/fphar.2022.982185 Text en Copyright © 2022 Marei, Ahmetaj-Shala and Triggle. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Marei, Isra Ahmetaj-Shala, Blerina Triggle, Chris R. Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes |
title | Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes |
title_full | Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes |
title_fullStr | Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes |
title_full_unstemmed | Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes |
title_short | Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes |
title_sort | biofunctionalization of cardiovascular stents to induce endothelialization: implications for in- stent thrombosis in diabetes |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589287/ https://www.ncbi.nlm.nih.gov/pubmed/36299902 http://dx.doi.org/10.3389/fphar.2022.982185 |
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