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Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes

Stent thrombosis remains one of the main causes that lead to vascular stent failure in patients undergoing percutaneous coronary intervention (PCI). Type 2 diabetes mellitus is accompanied by endothelial dysfunction and platelet hyperactivity and is associated with suboptimal outcomes following PCI,...

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Autores principales: Marei, Isra, Ahmetaj-Shala, Blerina, Triggle, Chris R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589287/
https://www.ncbi.nlm.nih.gov/pubmed/36299902
http://dx.doi.org/10.3389/fphar.2022.982185
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author Marei, Isra
Ahmetaj-Shala, Blerina
Triggle, Chris R.
author_facet Marei, Isra
Ahmetaj-Shala, Blerina
Triggle, Chris R.
author_sort Marei, Isra
collection PubMed
description Stent thrombosis remains one of the main causes that lead to vascular stent failure in patients undergoing percutaneous coronary intervention (PCI). Type 2 diabetes mellitus is accompanied by endothelial dysfunction and platelet hyperactivity and is associated with suboptimal outcomes following PCI, and an increase in the incidence of late stent thrombosis. Evidence suggests that late stent thrombosis is caused by the delayed and impaired endothelialization of the lumen of the stent. The endothelium has a key role in modulating inflammation and thrombosis and maintaining homeostasis, thus restoring a functional endothelial cell layer is an important target for the prevention of stent thrombosis. Modifications using specific molecules to induce endothelial cell adhesion, proliferation and function can improve stents endothelialization and prevent thrombosis. Blood endothelial progenitor cells (EPCs) represent a potential cell source for the in situ-endothelialization of vascular conduits and stents. We aim in this review to summarize the main biofunctionalization strategies to induce the in-situ endothelialization of coronary artery stents using circulating endothelial stem cells.
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spelling pubmed-95892872022-10-25 Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes Marei, Isra Ahmetaj-Shala, Blerina Triggle, Chris R. Front Pharmacol Pharmacology Stent thrombosis remains one of the main causes that lead to vascular stent failure in patients undergoing percutaneous coronary intervention (PCI). Type 2 diabetes mellitus is accompanied by endothelial dysfunction and platelet hyperactivity and is associated with suboptimal outcomes following PCI, and an increase in the incidence of late stent thrombosis. Evidence suggests that late stent thrombosis is caused by the delayed and impaired endothelialization of the lumen of the stent. The endothelium has a key role in modulating inflammation and thrombosis and maintaining homeostasis, thus restoring a functional endothelial cell layer is an important target for the prevention of stent thrombosis. Modifications using specific molecules to induce endothelial cell adhesion, proliferation and function can improve stents endothelialization and prevent thrombosis. Blood endothelial progenitor cells (EPCs) represent a potential cell source for the in situ-endothelialization of vascular conduits and stents. We aim in this review to summarize the main biofunctionalization strategies to induce the in-situ endothelialization of coronary artery stents using circulating endothelial stem cells. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9589287/ /pubmed/36299902 http://dx.doi.org/10.3389/fphar.2022.982185 Text en Copyright © 2022 Marei, Ahmetaj-Shala and Triggle. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Marei, Isra
Ahmetaj-Shala, Blerina
Triggle, Chris R.
Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes
title Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes
title_full Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes
title_fullStr Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes
title_full_unstemmed Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes
title_short Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes
title_sort biofunctionalization of cardiovascular stents to induce endothelialization: implications for in- stent thrombosis in diabetes
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589287/
https://www.ncbi.nlm.nih.gov/pubmed/36299902
http://dx.doi.org/10.3389/fphar.2022.982185
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