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Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response

BACKGROUND: Obstructive sleep apnoea (OSA) causes, among other things, intermittent blood oxygen desaturations, increasing the sympathetic tone. Yet the effect of desaturations on heart rate variability (HRV), a simple and noninvasive method for assessing sympathovagal balance, has not been comprehe...

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Autores principales: Hietakoste, Salla, Karhu, Tuomas, Sillanmäki, Saara, Bailón, Raquel, Penzel, Thomas, Töyräs, Juha, Leppänen, Timo, Myllymaa, Sami, Kainulainen, Samu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589326/
https://www.ncbi.nlm.nih.gov/pubmed/36299363
http://dx.doi.org/10.1183/23120541.00121-2022
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author Hietakoste, Salla
Karhu, Tuomas
Sillanmäki, Saara
Bailón, Raquel
Penzel, Thomas
Töyräs, Juha
Leppänen, Timo
Myllymaa, Sami
Kainulainen, Samu
author_facet Hietakoste, Salla
Karhu, Tuomas
Sillanmäki, Saara
Bailón, Raquel
Penzel, Thomas
Töyräs, Juha
Leppänen, Timo
Myllymaa, Sami
Kainulainen, Samu
author_sort Hietakoste, Salla
collection PubMed
description BACKGROUND: Obstructive sleep apnoea (OSA) causes, among other things, intermittent blood oxygen desaturations, increasing the sympathetic tone. Yet the effect of desaturations on heart rate variability (HRV), a simple and noninvasive method for assessing sympathovagal balance, has not been comprehensively studied. We aimed to study whether desaturation severity affects the immediate HRV. METHODS: We retrospectively analysed the electrocardiography signals in 5-min segments (n=39 132) recorded during clinical polysomnographies of 642 patients with suspected OSA. HRV parameters were calculated for each segment. The segments were pooled into severity groups based on the desaturation severity (i.e. the integrated area under the blood oxygen saturation curve) and the respiratory event rate within the segment. Covariate-adjusted regression analyses were performed to investigate possible confounding effects. RESULTS: With increasing respiratory event rate, the normalised high-frequency band power (HF(NU)) decreased from 0.517 to 0.364 (p<0.01), the normalised low-frequency band power (LF(NU)) increased from 0.483 to 0.636 (p<0.01) and the mean RR interval decreased from 915 to 869 ms (p<0.01). Similarly, with increasing desaturation severity, the HF(NU) decreased from 0.499 to 0.364 (p<0.01), the LF(NU) increased from 0.501 to 0.636 (p<0.01) and the mean RR interval decreased from 952 to 854 ms (p<0.01). Desaturation severity-related findings were confirmed by considering the confounding factors in the regression analyses. CONCLUSION: The short-term HRV response differs based on the desaturation severity and the respiratory event rate in patients with suspected OSA. Therefore, a more detailed analysis of HRV and desaturation characteristics could enhance OSA severity estimation.
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spelling pubmed-95893262022-10-25 Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response Hietakoste, Salla Karhu, Tuomas Sillanmäki, Saara Bailón, Raquel Penzel, Thomas Töyräs, Juha Leppänen, Timo Myllymaa, Sami Kainulainen, Samu ERJ Open Res Original Research Articles BACKGROUND: Obstructive sleep apnoea (OSA) causes, among other things, intermittent blood oxygen desaturations, increasing the sympathetic tone. Yet the effect of desaturations on heart rate variability (HRV), a simple and noninvasive method for assessing sympathovagal balance, has not been comprehensively studied. We aimed to study whether desaturation severity affects the immediate HRV. METHODS: We retrospectively analysed the electrocardiography signals in 5-min segments (n=39 132) recorded during clinical polysomnographies of 642 patients with suspected OSA. HRV parameters were calculated for each segment. The segments were pooled into severity groups based on the desaturation severity (i.e. the integrated area under the blood oxygen saturation curve) and the respiratory event rate within the segment. Covariate-adjusted regression analyses were performed to investigate possible confounding effects. RESULTS: With increasing respiratory event rate, the normalised high-frequency band power (HF(NU)) decreased from 0.517 to 0.364 (p<0.01), the normalised low-frequency band power (LF(NU)) increased from 0.483 to 0.636 (p<0.01) and the mean RR interval decreased from 915 to 869 ms (p<0.01). Similarly, with increasing desaturation severity, the HF(NU) decreased from 0.499 to 0.364 (p<0.01), the LF(NU) increased from 0.501 to 0.636 (p<0.01) and the mean RR interval decreased from 952 to 854 ms (p<0.01). Desaturation severity-related findings were confirmed by considering the confounding factors in the regression analyses. CONCLUSION: The short-term HRV response differs based on the desaturation severity and the respiratory event rate in patients with suspected OSA. Therefore, a more detailed analysis of HRV and desaturation characteristics could enhance OSA severity estimation. European Respiratory Society 2022-10-24 /pmc/articles/PMC9589326/ /pubmed/36299363 http://dx.doi.org/10.1183/23120541.00121-2022 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by/4.0/This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.
spellingShingle Original Research Articles
Hietakoste, Salla
Karhu, Tuomas
Sillanmäki, Saara
Bailón, Raquel
Penzel, Thomas
Töyräs, Juha
Leppänen, Timo
Myllymaa, Sami
Kainulainen, Samu
Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
title Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
title_full Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
title_fullStr Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
title_full_unstemmed Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
title_short Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
title_sort obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589326/
https://www.ncbi.nlm.nih.gov/pubmed/36299363
http://dx.doi.org/10.1183/23120541.00121-2022
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